Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P56749 | CLDN12 | Claudin-12 | Homo sapiens (Human) | 244 aa |
Protein Details: P56749 (CLDN12)
Protein Information
| Accession | P56749 |
|---|---|
| Protein Names | Claudin-12 |
| Gene Symbol | CLDN12 |
| Organism | Homo sapiens (Human) |
| Length | 244 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.921
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
35
LNCaP cells
Specificity: 0.921
35/46 (76.1%)
3
PC3 cells
Specificity: 0.079
3/4 (75.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGCRDVHAAT11VLSFLCGIAS21VAGLFAGTLL31PNWRKLRLIT41FNRNEKNLTV
51-10051YTGLWVKCAR61YDGSSDCLMY71DTTWYSSVDQ81LDLRVLQFAL91PLSMLIAMGA
101-150101LLLCLIGMCN111TAFRSSVPNI121KLAKCLVNSA131GCHLVAGLLF141FLAGTVSLSP
151-200151SIWVIFYNIH161LNKKFEPVFS171FDYAVYVTIA181SAGGLFMTSL191ILFIWYCTCK
201-244201SLPSPFWQPL211YSHPPSMHTY221SQPYSARSRL231SAIEIDIPVV241SHTT
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 3 | Prediction (High) | - | - |
| 58 | Prediction (Low) | - | - |
| 104 | Prediction (Medium) | - | - |
| 109 | Prediction (Medium) | - | - |
| 125 | CYSMODDB SWISSPALM DBPTM Prediction (Low) | - | - |
| 132 | Prediction (Low) | - | - |
| 197 | Prediction (Medium) | - | - |
| 199 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 151 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |