Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P56818 Bace1 Beta-secretase 1 (EC 3.4.23.46) (Aspartyl … Mus musculus (Mouse) 501 aa

Protein Details: P56818 (Bace1)

Protein Information
AccessionP56818
Protein NamesBeta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)
Gene SymbolBace1
OrganismMus musculus (Mouse)
Length501 aa
IsoformsNo isoforms
Related PMIDs 31772009 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass)
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAPALHWLLL11WVGSGMLPAQ21GTHLGIRLPL31RSGLAGPPLG41LRLPRETDEE
51-10051SEEPGRRGSF61VEMVDNLRGK71SGQGYYVEMT81VGSPPQTLNI91LVDTGSSNFA
101-150101VGAAPHPFLH111RYYQRQLSST121YRDLRKGVYV131PYTQGKWEGE141LGTDLVSIPH
151-200151GPNVTVRANI161AAITESDKFF171INGSNWEGIL181GLAYAEIARP191DDSLEPFFDS
201-250201LVKQTHIPNI211FSLQLCGAGF221PLNQTEALAS231VGGSMIIGGI241DHSLYTGSLW
251-300251YTPIRREWYY261EVIIVRVEIN271GQDLKMDCKE281YNYDKSIVDS291GTTNLRLPKK
301-350301VFEAAVKSIK311AASSTEKFPD321GFWLGEQLVC331WQAGTTPWNI341FPVISLYLMG
351-400351EVTNQSFRIT361ILPQQYLRPV371EDVATSQDDC381YKFAVSQSST391GTVMGAVIME
401-450401GFYVVFDRAR411KRIGFAVSAC421HVHDEFRTAA431VEGPFVTADM441EDCGYNIPQT
451-500451DESTLMTIAY461VMAAICALFM471LPLCLMVCQW481RCLRCLRHQH491DDFADDISLL
501-501501K
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
216 - - -
Deep-Palm: 0.75
278 - - -
Deep-Palm: 0.07
330 - - -
Deep-Palm: 0.34
380 - -
Brain (35358180)
Deep-Palm: 0.61
420 - - -
GPS-Palm: 0.84
Deep-Palm: 0.88
443 - - -
Deep-Palm: 0.22
466 - - -
Deep-Palm: 0.09
474 DBPTM SWISSPALM - - -
GPS-Palm: 0.90
Deep-Palm: 0.43
478 DBPTM SWISSPALM - - -
GPS-Palm: 0.96
Deep-Palm: 0.66
482 DBPTM SWISSPALM - - -
GPS-Palm: 0.92
Deep-Palm: 0.56
485 DBPTM SWISSPALM - - -
GPS-Palm: 0.86
Deep-Palm: 0.41
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
NSC
Specificity: 0.100
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
9
Brain tissue (Mass)
Specificity: 0.900
9/56 (16.1%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine