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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P56937 HSD17B7 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid … Homo sapiens (Human) 341 aa

Protein Details: P56937 (HSD17B7)

Protein Information
AccessionP56937
Protein Names3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 37C member 1)
Gene SymbolHSD17B7
OrganismHomo sapiens (Human)
Length341 aa
IsoformsNo isoforms
Related PMIDs 29733200
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MRKVVLITGA11SSGIGLALCK21RLLAEDDELH31LCLACRNMSK41AEAVCAALLA
51-10051SHPTAEVTIV61QVDVSNLQSV71FRASKELKQR81FQRLDCIYLN91AGIMPNPQLN
101-150101IKALFFGLFS111RKVIHMFSTA121EGLLTQGDKI131TADGLQEVFE141TNVFGHFILI
151-200151RELEPLLCHS161DNPSQLIWTS171SRSARKSNFS181LEDFQHSKGK191EPYSSSKYAT
201-250201DLLSVALNRN211FNQQGLYSNV221ACPGTALTNL231TYGILPPFIW241TLLMPAILLL
251-300251RFFANAFTLT261PYNGTEALVW271LFHQKPESLN281PLIKYLSATT291GFGRNYIMTQ
301-341301KMDLDEDTAE311KFYQKLLELE321KHIRVTIQKT331DNQARLSGSC341L
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
19 3-Keto-Steroid Reductase/17-beta-Hydroxysteroid Dehydrogenase NAD(P)-binding domain superfamily Short-chain dehydrogenase/reductase SDR - -
GPS-Palm: 0.90
Deep-Palm: 0.98
32 3-Keto-Steroid Reductase/17-beta-Hydroxysteroid Dehydrogenase NAD(P)-binding domain superfamily - -
Deep-Palm: 0.98
35 3-Keto-Steroid Reductase/17-beta-Hydroxysteroid Dehydrogenase NAD(P)-binding domain superfamily - -
Deep-Palm: 0.98
45 3-Keto-Steroid Reductase/17-beta-Hydroxysteroid Dehydrogenase NAD(P)-binding domain superfamily - -
Deep-Palm: 0.97
86 - - -
GPS-Palm: 0.71
Deep-Palm: 0.95
158 - - -
Deep-Palm: 0.96
222 - - -
GPS-Palm: 0.76
Deep-Palm: 0.88
340 - - -
GPS-Palm: 0.97
Deep-Palm: 0.04
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
HAP1 cell
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
32 C → C 0.001887 SNP Silent UCEC
74 S → C 0.001887 SNP Missense Mutation UCEC
81 F → C 0.002288 SNP Missense Mutation STAD
172 R → C 0.003460 SNP Missense Mutation CESC
179 F → C 0.005618 SNP Missense Mutation PAAD
222 C → S 0.012500 SNP Missense Mutation UVM
251 R → C 0.002427 SNP Missense Mutation BLCA
254 A → Cfs*10 0.001887 INS Frame Shift Ins UCEC