Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P57764 | GSDMD | Gasdermin-D (Gasdermin domain-containing protein 1) … | Homo sapiens (Human) | 484 aa |
Protein Details: P57764 (GSDMD)
Protein Information
| Accession | P57764 |
|---|---|
| Protein Names | Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (hGSDMD-NTD); Gasdermin-D, C-terminal (GSDMD-CT) (hGSDMD-CTD); Gasdermin-D, p13 (Gasdermin-D, 13 kDa) (13 kDa GSDMD); Gasdermin-D, p40] |
| Gene Symbol | GSDMD |
| Organism | Homo sapiens (Human) |
| Length | 484 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGSAFERVVR11RVVQELDHGG21EFIPVTSLQS31STGFQPYCLV41VRKPSSSWFW
51-10051KPRYKCVNLS61IKDILEPDAA71EPDVQRGRSF81HFYDAMDGQI91QGSVELAAPG
101-150101QAKIAGGAAV111SDSSSTSMNV121YSLSVDPNTW131QTLLHERHLR141QPEHKVLQQL
151-200151RSRGDNVYVV161TEVLQTQKEV171EVTRTHKREG181SGRFSLPGAT191CLQGEGQGHL
201-250201SQKKTVTIPS211GSTLAFRVAQ221LVIDSDLDVL231LFPDKKQRTF241QPPATGHKRS
251-300251TSEGAWPQLP261SGLSMMRCLH271NFLTDGVPAE281GAFTEDFQGL291RAEVETISKE
301-350301LELLDRELCQ311LLLEGLEGVL321RDQLALRALE331EALEQGQSLG341PVEPLDGPAG
351-400351AVLECLVLSS361GMLVPELAIP371VVYLLGALTM381LSETQHKLLA391EALESQTLLG
401-450401PLELVGSLLE411QSAPWQERST421MSLPPGLLGN431SWGEGAPAWV441LLDECGLELG
451-484451EDTPHVCWEP461QAQGRMCALY471ASLALLSGLS481QEPH
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 38 | Gasdermin Gasdermin, pore forming domain | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.68
|
|
| 56 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.77
|
|
| 191 | SWISSPALM | Gasdermin pore forming domain | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.96
|
| 268 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.93
|
|
| 309 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.98
|
|
| 355 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.98
|
|
| 445 | - | - | - |
Deep-Palm: 0.92
|
|
| 457 | - | - | - |
Deep-Palm: 0.74
|
|
| 467 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 77 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 158 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 225 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 298 | S → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 309 | C → G | 0.001887 | SNP | Missense Mutation | UCEC |