Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P57764 | GSDMD; DFNA5L; GSDMDC1; FKSG10 | Gasdermin-D (Gasdermin domain-containing protein 1) … | Homo sapiens (Human) | 484 aa |
Protein Details: P57764 (GSDMD)
Protein Information
| Accession | P57764 |
|---|---|
| Protein Names | Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (hGSDMD-NTD); Gasdermin-D, C-terminal (GSDMD-CT) (hGSDMD-CTD); Gasdermin-D, p13 (Gasdermin-D, 13 kDa) (13 kDa GSDMD); Gasdermin-D, p40] |
| Gene Symbol | GSDMD; DFNA5L; GSDMDC1; FKSG10 |
| Organism | Homo sapiens (Human) |
| Length | 484 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGSAFERVVR11RVVQELDHGG21EFIPVTSLQS31STGFQPYCLV41VRKPSSSWFW
51-10051KPRYKCVNLS61IKDILEPDAA71EPDVQRGRSF81HFYDAMDGQI91QGSVELAAPG
101-150101QAKIAGGAAV111SDSSSTSMNV121YSLSVDPNTW131QTLLHERHLR141QPEHKVLQQL
151-200151RSRGDNVYVV161TEVLQTQKEV171EVTRTHKREG181SGRFSLPGAT191CLQGEGQGHL
201-250201SQKKTVTIPS211GSTLAFRVAQ221LVIDSDLDVL231LFPDKKQRTF241QPPATGHKRS
251-300251TSEGAWPQLP261SGLSMMRCLH271NFLTDGVPAE281GAFTEDFQGL291RAEVETISKE
301-350301LELLDRELCQ311LLLEGLEGVL321RDQLALRALE331EALEQGQSLG341PVEPLDGPAG
351-400351AVLECLVLSS361GMLVPELAIP371VVYLLGALTM381LSETQHKLLA391EALESQTLLG
401-450401PLELVGSLLE411QSAPWQERST421MSLPPGLLGN431SWGEGAPAWV441LLDECGLELG
451-484451EDTPHVCWEP461QAQGRMCALY471ASLALLSGLS481QEPH
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 38 | Prediction (Medium) | - | - |
| 56 | Prediction (Low) | - | - |
| 191 | SWISSPALM Prediction (Low) | Gasdermin pore forming domain | - |
| 309 | Prediction (Low) | - | - |
| 355 | Prediction (Low) | - | - |
| 467 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 77 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 158 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 225 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 298 | S → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 309 | C → G | 0.001887 | SNP | Missense Mutation | UCEC |