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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P61006 RAB8A Ras-related protein Rab-8A (EC 3.6.5.2) … Homo sapiens (Human) 207 aa

Protein Details: P61006 (RAB8A)

Protein Information
AccessionP61006
Protein NamesRas-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)
Gene SymbolRAB8A
OrganismHomo sapiens (Human)
Length207 aa
IsoformsNo isoforms
Related PMIDs 26876311 29733200
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAKTYDYLFK11LLLIGDSGVG21KTCVLFRFSE31DAFNSTFIST41IGIDFKIRTI
51-10051ELDGKRIKLQ61IWDTAGQERF71RTITTAYYRG81AMGIMLVYDI91TNEKSFDNIR
101-150101NWIRNIEEHA111SADVEKMILG121NKCDVNDKRQ131VSKERGEKLA141LDYGIKFMET
151-200151SAKANINVEN161AFFTLARDIK171AKMDKKLEGN181SPQGSNQGVK191ITPDQQKRSS
201-207201FFRCVLL
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
23 SWISSPALM DBPTM CYSMODDB Ras family Small GTPase superfamily, Rab P-loop containing nucleoside triphosphate hydrolase Transforming protein P21 ras signature Small GTPase small GTPase Rab1 family profile. - -
GPS-Palm: 0.70
Deep-Palm: 0.96
123 - - -
GPS-Palm: 0.77
Deep-Palm: 0.91
204 - - -
GPS-Palm: 0.96
Deep-Palm: 0.02
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
2
HAP1 cell
Specificity: 0.500
2/2 (100.0%)
1
frontal cortex
Specificity: 0.250
1/1 (100.0%)
1
293T cell
Specificity: 0.250
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
23 C → R 0.002427 SNP Missense Mutation BLCA
27 R → C 0.002141 SNP Missense Mutation SKCM
104 R → C 0.009434 SNP Missense Mutation UCEC
143 Y → C 0.001764 SNP Missense Mutation LUAD
? ? → ? 0.010870 SNP Missense Mutation ACC