Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P61158 | ACTR3 | Actin-related protein 3 (Actin-like protein … | Homo sapiens (Human) | 418 aa |
Protein Details: P61158 (ACTR3)
Protein Information
| Accession | P61158 |
|---|---|
| Protein Names | Actin-related protein 3 (Actin-like protein 3) |
| Gene Symbol | ACTR3 |
| Organism | Homo sapiens (Human) |
| Length | 418 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAGRLPACVV11DCGTGYTKLG21YAGNTEPQFI31IPSCIAIKES41AKVGDQAQRR
51-10051VMKGVDDLDF61FIGDEAIEKP71TYATKWPIRH81GIVEDWDLME91RFMEQVIFKY
101-150101LRAEPEDHYF111LLTEPPLNTP121ENREYTAEIM131FESFNVPGLY141IAVQAVLALA
151-200151ASWTSRQVGE161RTLTGTVIDS171GDGVTHVIPV181AEGYVIGSCI191KHIPIAGRDI
201-250201TYFIQQLLRD211REVGIPPEQS221LETAKAVKER231YSYVCPDLVK241EFNKYDTDGS
251-300251KWIKQYTGIN261AISKKEFSID271VGYERFLGPE281IFFHPEFANP291DFTQPISEVV
301-350301DEVIQNCPID311VRRPLYKNIV321LSGGSTMFRD331FGRRLQRDLK341RTVDARLKLS
351-400351EELSGGRLKP361KPIDVQVITH371HMQRYAVWFG381GSMLASTPEF391YQVCHTKKDY
401-418401EEIGPSICRH411NPVFGVMS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 8 | SWISSPALM DBPTM CYSMODDB | ATPase, nucleotide binding domain Actin |
SW480 cell line
(26865113)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.92
Deep-Palm: 0.11
|
| 12 | SWISSPALM DBPTM CYSMODDB | Actin ATPase, nucleotide binding domain Actin family |
SW480 cell line
(26865113)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.76
Deep-Palm: 0.65
|
| 34 | ATPase, nucleotide binding domain Actin family |
SW480 cell line
(26865113)
| - |
GPS-Palm: 0.81
Deep-Palm: 0.75
|
|
| 189 | SWISSPALM DBPTM CYSMODDB | Actin |
HeLa
(29575903)
| - |
GPS-Palm: 0.82
Deep-Palm: 0.77
|
| 235 | - |
SW480 cell line
(26865113)
| - |
GPS-Palm: 0.84
Deep-Palm: 0.89
|
|
| 307 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.77
|
|
| 394 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.25
|
|
| 408 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
2
cerebral cortex
Specificity: 0.250
2/2 (100.0%)
1
LNCaP
Specificity: 0.125
1/1 (100.0%)
1
HAP1 cell
Specificity: 0.125
1/1 (100.0%)
1
293T cell
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.375
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 34 | C → C | 0.001887 | SNP | Splice Region | UCEC |
| 230 | R → C | 0.007299 | SNP | Missense Mutation | READ |