Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P61163 | ACTR1A | Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated … | Homo sapiens (Human) | 376 aa |
Protein Details: P61163 (ACTR1A)
Protein Information
| Accession | P61163 |
|---|---|
| Protein Names | Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) |
| Gene Symbol | ACTR1A |
| Organism | Homo sapiens (Human) |
| Length | 376 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MESYDVIANQ11PVVIDNGSGV21IKAGFAGDQI31PKYCFPNYVG41RPKHVRVMAG
51-10051ALEGDIFIGP61KAEEHRGLLS71IRYPMEHGIV81KDWNDMERIW91QYVYSKDQLQ
101-150101TFSEEHPVLL111TEAPLNPRKN121RERAAEVFFE131TFNVPALFIS141MQAVLSLYAT
151-200151GRTTGVVLDS161GDGVTHAVPI171YEGFAMPHSI181MRIDIAGRDV191SRFLRLYLRK
201-250201EGYDFHSSSE211FEIVKAIKER221ACYLSINPQK231DETLETEKAQ241YYLPDGSTIE
251-300251IGPSRFRAPE261LLFRPDLIGE271ESEGIHEVLV281FAIQKSDMDL291RRTLFSNIVL
301-350301SGGSTLFKGF311GDRLLSEVKK321LAPKDVKIRI331SAPQERLYST341WIGGSILASL
351-376351DTFKKMWVSK361KEYEEDGARS371IHRKTF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 34 | ATPase, nucleotide binding domain Actin family | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.77
|
|
| 222 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.76
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
2
cerebral cortex
Specificity: 0.400
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.200
1/1 (100.0%)
1
heart
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
Cerebral Cortex (Mass)
Specificity: 0.200
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 18 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 46 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 140 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 197 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 241 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 252 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 281 | F → C | 0.002506 | SNP | Missense Mutation | COAD |
| 292 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 292 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 376 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |