Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P61221 ABCE1; RLI; RNASEL1; RNASELI; RNS4I; OK/SW-cl.40 ATP-binding cassette sub-family E member … Homo sapiens (Human) 599 aa

Protein Details: P61221 (ABCE1)

Protein Information
Accession P61221
Protein Names ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I)
Gene Symbol ABCE1; RLI; RNASEL1; RNASELI; RNS4I; OK/SW-cl.40
Organism Homo sapiens (Human)
Length 599 aa
Isoforms No isoforms
Related PMIDs 22496122 29733200 31251020
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.605
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
23
LNCaP cells
Specificity: 0.605
23/46 (50.0%)
10
HAP1 cells
Specificity: 0.263
10/10 (100.0%)
4
293T cells
Specificity: 0.105
4/10 (40.0%)
1
Endothelial cells
Specificity: 0.026
1/2 (50.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MADKLTRIAI11VNHDKCKPKK21CRQECKKSCP31VVRMGKLCIE41VTPQSKIAWI
51-10051SETLCIGCGI61CIKKCPFGAL71SIVNLPSNLE81KETTHRYCAN91AFKLHRLPIP
101-150101RPGEVLGLVG111TNGIGKSTAL121KILAGKQKPN131LGKYDDPPDW141QEILTYFRGS
151-200151ELQNYFTKIL161EDDLKAIIKP171QYVDQIPKAA181KGTVGSILDR191KDETKTQAIV
201-250201CQQLDLTHLK211ERNVEDLSGG221ELQRFACAVV231CIQKADIFMF241DEPSSYLDVK
251-300251QRLKAAITIR261SLINPDRYII271VVEHDLSVLD281YLSDFICCLY291GVPSAYGVVT
301-350301MPFSVREGIN311IFLDGYVPTE321NLRFRDASLV331FKVAETANEE341EVKKMCMYKY
351-400351PGMKKKMGEF361ELAIVAGEFT371DSEIMVMLGE381NGTGKTTFIR391MLAGRLKPDE
401-450401GGEVPVLNVS411YKPQKISPKS421TGSVRQLLHE431KIRDAYTHPQ441FVTDVMKPLQ
451-500451IENIIDQEVQ461TLSGGELQRV471ALALCLGKPA481DVYLIDEPSA491YLDSEQRLMA
501-550501ARVVKRFILH511AKKTAFVVEH521DFIMATYLAD531RVIVFDGVPS541KNTVANSPQT
551-599551LLAGMNKFLS561QLEITFRRDP571NNYRPRINKL581NSIKDVEQKK591SGNYFFLDD
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
16 Prediction (Low) - -
25 Prediction (Medium) - -
29 Prediction (Medium) - -
38 Prediction (High) - -
55 Prediction (High) - -
58 Prediction (Low) - -
61 Prediction (Medium) - -
65 CYSMODDB SWISSPALM DBPTM Prediction (Medium) 4Fe-4S binding domain -
88 Prediction (Low) - -
201 Prediction (Low) - -
227 CYSMODDB SWISSPALM DBPTM Prediction (High) ABC transporter -
231 CYSMODDB SWISSPALM DBPTM Prediction (Medium) ABC transporter -
346 Prediction (Medium) - -
475 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
88 C → Y 0.001887 SNP Missense Mutation UCEC
134 Y → C 0.002747 SNP Missense Mutation LIHC
225 F → C 0.001887 SNP Missense Mutation UCEC
287 C → C 0.001887 SNP Silent UCEC
290 Y → C 0.001014 SNP Missense Mutation BRCA
346 C → C 0.002506 SNP Silent COAD
425 R → C 0.002506 SNP Missense Mutation COAD
425 R → C 0.007299 SNP Missense Mutation READ
425 R → C 0.001887 SNP Missense Mutation UCEC
483 Y → C 0.015152 SNP Missense Mutation KICH
506 R → C 0.001887 SNP Missense Mutation UCEC
527 Y → C 0.015152 SNP Missense Mutation KICH