Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P61221 | ABCE1 | ATP-binding cassette sub-family E member … | Homo sapiens (Human) | 599 aa |
Protein Details: P61221 (ABCE1)
Protein Information
| Accession | P61221 |
|---|---|
| Protein Names | ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) |
| Gene Symbol | ABCE1 |
| Organism | Homo sapiens (Human) |
| Length | 599 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 29733200 31251020 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MADKLTRIAI11VNHDKCKPKK21CRQECKKSCP31VVRMGKLCIE41VTPQSKIAWI
51-10051SETLCIGCGI61CIKKCPFGAL71SIVNLPSNLE81KETTHRYCAN91AFKLHRLPIP
101-150101RPGEVLGLVG111TNGIGKSTAL121KILAGKQKPN131LGKYDDPPDW141QEILTYFRGS
151-200151ELQNYFTKIL161EDDLKAIIKP171QYVDQIPKAA181KGTVGSILDR191KDETKTQAIV
201-250201CQQLDLTHLK211ERNVEDLSGG221ELQRFACAVV231CIQKADIFMF241DEPSSYLDVK
251-300251QRLKAAITIR261SLINPDRYII271VVEHDLSVLD281YLSDFICCLY291GVPSAYGVVT
301-350301MPFSVREGIN311IFLDGYVPTE321NLRFRDASLV331FKVAETANEE341EVKKMCMYKY
351-400351PGMKKKMGEF361ELAIVAGEFT371DSEIMVMLGE381NGTGKTTFIR391MLAGRLKPDE
401-450401GGEVPVLNVS411YKPQKISPKS421TGSVRQLLHE431KIRDAYTHPQ441FVTDVMKPLQ
451-500451IENIIDQEVQ461TLSGGELQRV471ALALCLGKPA481DVYLIDEPSA491YLDSEQRLMA
501-550501ARVVKRFILH511AKKTAFVVEH521DFIMATYLAD531RVIVFDGVPS541KNTVANSPQT
551-599551LLAGMNKFLS561QLEITFRRDP571NNYRPRINKL581NSIKDVEQKK591SGNYFFLDD
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 16 | RLI1 RNase L inhibitor RLI-like, possible metal-binding domain | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.23
|
|
| 21 | RLI1 RNase L inhibitor RLI-like, possible metal-binding domain | - | - |
Deep-Palm: 0.46
|
|
| 25 | RLI1 RNase L inhibitor RLI-like, possible metal-binding domain | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.56
|
|
| 29 | RLI1 RNase L inhibitor RLI-like, possible metal-binding domain | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.74
|
|
| 38 | 4Fe-4S ferredoxins P-loop containing nucleoside triphosphate hydrolase 4Fe-4S ferredoxin-type, iron-sulphur binding domain RLI1 | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.89
|
|
| 55 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.90
|
|
| 58 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.91
|
|
| 61 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.89
|
|
| 65 | SWISSPALM DBPTM CYSMODDB | 4Fe-4S binding domain | - |
Unknown
(32651440)
|
GPS-Palm: 0.85
Deep-Palm: 0.95
|
| 88 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.85
|
|
| 201 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.95
|
|
| 227 | SWISSPALM DBPTM CYSMODDB | ABC transporter | - |
Unknown
(32651440)
|
GPS-Palm: 0.93
Deep-Palm: 0.94
|
| 231 | SWISSPALM DBPTM CYSMODDB | ABC transporter | - |
Unknown
(32651440)
|
GPS-Palm: 0.79
Deep-Palm: 0.93
|
| 287 | - | - | - |
Deep-Palm: 0.91
|
|
| 288 | - | - | - |
Deep-Palm: 0.85
|
|
| 346 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.53
|
|
| 475 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
2
LNCaP
Specificity: 0.333
2/2 (100.0%)
2
HAP1 cell
Specificity: 0.333
2/2 (100.0%)
1
EC cell
Specificity: 0.167
1/1 (100.0%)
1
293T cell
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 88 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 134 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 225 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 287 | C → C | 0.001887 | SNP | Silent | UCEC |
| 290 | Y → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 346 | C → C | 0.002506 | SNP | Silent | COAD |
| 425 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 425 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 425 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 483 | Y → C | 0.015152 | SNP | Missense Mutation | KICH |
| 506 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 527 | Y → C | 0.015152 | SNP | Missense Mutation | KICH |