Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P61225 | RAP2B | Ras-related protein Rap-2b (EC 3.6.5.2) | Homo sapiens (Human) | 183 aa |
Protein Details: P61225 (RAP2B)
Protein Information
| Accession | P61225 |
|---|---|
| Protein Names | Ras-related protein Rap-2b (EC 3.6.5.2) |
| Gene Symbol | RAP2B |
| Organism | Homo sapiens (Human) |
| Length | 183 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 19801377 22496122 24357059 25914232 26111759 29575903 29733200 31251020 31382980 32651440 32944167 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MREYKVVVLG11SGGVGKSALT21VQFVTGSFIE31KYDPTIEDFY41RKEIEVDSSP
51-10051SVLEILDTAG61TEQFASMRDL71YIKNGQGFIL81VYSLVNQQSF91QDIKPMRDQI
101-150101IRVKRYERVP111MILVGNKVDL121EGEREVSYGE131GKALAEEWSC141PFMETSAKNK
151-183151ASVDELFAEI161VRQMNYAAQP171NGDEGCCSAC181VIL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 140 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
GPS-Palm: 0.75
Deep-Palm: 0.96
|
|
| 176 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.02
|
| 177 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.02
|
| 180 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.243
9
Jurkat T cell
Specificity: 0.214
9/9 (100.0%)
4
Primary T cell
Specificity: 0.095
4/4 (100.0%)
4
PC3
Specificity: 0.095
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.095
4/4 (100.0%)
3
LNCaP
Specificity: 0.071
3/3 (100.0%)
3
CEM 174 cell
Specificity: 0.071
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.048
2/2 (100.0%)
2
HeLa cell
Specificity: 0.048
2/2 (100.0%)
1
U937 cell
Specificity: 0.024
1/1 (100.0%)
1
EC cell
Specificity: 0.024
1/1 (100.0%)
1
293T cell
Specificity: 0.024
1/1 (100.0%)
1
heart
Specificity: 0.024
1/1 (100.0%)
1
HUVECs
Specificity: 0.024
1/1 (100.0%)
1
DU145 cell
Specificity: 0.024
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.095
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.024
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 71 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 82 | Y → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 138 | W → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 176 | C → R | 0.002506 | SNP | Missense Mutation | COAD |