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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P61225 RAP2B Ras-related protein Rap-2b (EC 3.6.5.2) Homo sapiens (Human) 183 aa

Protein Details: P61225 (RAP2B)

Protein Information
Accession P61225
Protein Names Ras-related protein Rap-2b (EC 3.6.5.2)
Gene Symbol RAP2B
Organism Homo sapiens (Human)
Length 183 aa
Isoforms No isoforms
Related PMIDs 19137006 19801377 21076176 22496122 24357059 25914232 26111759 29575903 29733200 31251020 31382980 32651440 32944167 33636221 36430497
Database Sources dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.407
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
35
LNCaP cells
Specificity: 0.407
35/46 (76.1%)
15
Jurkat T cells
Specificity: 0.174
15/25 (60.0%)
10
HAP1 cells
Specificity: 0.116
10/10 (100.0%)
4
PC3 cells
Specificity: 0.047
4/4 (100.0%)
4
T cells
Specificity: 0.047
4/4 (100.0%)
4
293T cells
Specificity: 0.047
4/10 (40.0%)
4
Cerebral cortex
Specificity: 0.047
4/4 (100.0%)
3
CEMx174 cells
Specificity: 0.035
3/3 (100.0%)
2
DU145 cells
Specificity: 0.023
2/2 (100.0%)
2
Endothelial cells
Specificity: 0.023
2/2 (100.0%)
1
U937 cells
Specificity: 0.012
1/1 (100.0%)
1
HeLa cells
Specificity: 0.012
1/1 (100.0%)
1
Liver membrane
Specificity: 0.012
1/1 (100.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MREYKVVVLG11SGGVGKSALT21VQFVTGSFIE31KYDPTIEDFY41RKEIEVDSSP
51-10051SVLEILDTAG61TEQFASMRDL71YIKNGQGFIL81VYSLVNQQSF91QDIKPMRDQI
101-150101IRVKRYERVP111MILVGNKVDL121EGEREVSYGE131GKALAEEWSC141PFMETSAKNK
151-183151ASVDELFAEI161VRQMNYAAQP171NGDEGCCSAC181VIL
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
140 Prediction (Low) - -
176 DBPTM SWISSPALM Prediction (Low) - -
177 DBPTM SWISSPALM Prediction (Medium) - -
180 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
71 Y → C 0.001887 SNP Missense Mutation UCEC
82 Y → C 0.001014 SNP Missense Mutation BRCA
138 W → C 0.001014 SNP Missense Mutation BRCA
176 C → R 0.002506 SNP Missense Mutation COAD