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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P61586 RHOA; ARH12; ARHA; RHO12 Transforming protein RhoA (EC 3.6.5.2) … Homo sapiens (Human) 193 aa

Protein Details: P61586 (RHOA)

Protein Information
Accession P61586
Protein Names Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene Symbol RHOA; ARH12; ARHA; RHO12
Organism Homo sapiens (Human)
Length 193 aa
Isoforms No isoforms
Related PMIDs 19801377 26876311 29575903 29733200 31251020 32944167 33636221
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.471
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
24
LNCaP cells
Specificity: 0.471
24/46 (52.2%)
10
HAP1 cells
Specificity: 0.196
10/10 (100.0%)
10
293T cells
Specificity: 0.196
10/10 (100.0%)
3
PC3 cells
Specificity: 0.059
3/4 (75.0%)
2
DU145 cells
Specificity: 0.039
2/2 (100.0%)
1
Prefrontal cortex
Specificity: 0.020
1/1 (100.0%)
1
Liver membrane
Specificity: 0.020
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAAIRKKLVI11VGDGACGKTC21LLIVFSKDQF31PEVYVPTVFE41NYVADIEVDG
51-10051KQVELALWDT61AGQEDYDRLR71PLSYPDTDVI81LMCFSIDSPD91SLENIPEKWT
101-150101PEVKHFCPNV111PIILVGNKKD121LRNDEHTRRE131LAKMKQEPVK141PEEGRDMANR
151-193151IGAFGYMECS161AKTKDGVREV171FEMATRAALQ181ARRGKKKSGC191LVL
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
16 Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) Ras family 29575903
20 Prediction (Low) - -
107 Experimental CYSMODDB SWISSPALM DBPTM Ras family 29575903
159 Prediction (High) - -
190 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
16 C → S 0.007299 SNP Missense Mutation READ
20 C → G 0.002427 SNP Missense Mutation BLCA
34 Y → C 0.004577 SNP Missense Mutation STAD
34 Y → C 0.005435 SNP Missense Mutation ESCA
39 F → C 0.002288 SNP Missense Mutation STAD
42 Y → C 0.006865 SNP Missense Mutation STAD
68 R → C 0.002545 SNP Missense Mutation GBM
107 C → C 0.001887 SNP Silent UCEC
152 G → C 0.002294 SNP Missense Mutation OV
154 F → C 0.007299 SNP Missense Mutation READ
183 R → C 0.001887 SNP Missense Mutation UCEC