Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P61586 | RHOA | Transforming protein RhoA (EC 3.6.5.2) … | Homo sapiens (Human) | 193 aa |
Protein Details: P61586 (RHOA)
Protein Information
| Accession | P61586 |
|---|---|
| Protein Names | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) |
| Gene Symbol | RHOA |
| Organism | Homo sapiens (Human) |
| Length | 193 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 29733200 31251020 33636221 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAIRKKLVI11VGDGACGKTC21LLIVFSKDQF31PEVYVPTVFE41NYVADIEVDG
51-10051KQVELALWDT61AGQEDYDRLR71PLSYPDTDVI81LMCFSIDSPD91SLENIPEKWT
101-150101PEVKHFCPNV111PIILVGNKKD121LRNDEHTRRE131LAKMKQEPVK141PEEGRDMANR
151-193151IGAFGYMECS161AKTKDGVREV171FEMATRAALQ181ARRGKKKSGC191LVL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 16 | SWISSPALM DBPTM CYSMODDB | Ras family P-loop containing nucleoside triphosphate hydrolase Transforming protein P21 ras signature Small GTPase Small GTPase Rho | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.98
|
| 20 | P-loop containing nucleoside triphosphate hydrolase Transforming protein P21 ras signature Small GTPase Small GTPase Rho | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.75
Deep-Palm: 0.97
|
|
| 83 | - | - | - |
Deep-Palm: 0.82
|
|
| 107 | SWISSPALM DBPTM CYSMODDB | Ras family | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
Deep-Palm: 0.97
|
| 159 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.96
|
|
| 190 | - | - | - |
GPS-Palm: 0.98
Deep-Palm: 0.07
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.250
2
LNCaP
Specificity: 0.250
2/2 (100.0%)
2
HAP1 cell
Specificity: 0.250
2/2 (100.0%)
2
293T cell
Specificity: 0.250
2/2 (100.0%)
1
frontal cortex
Specificity: 0.125
1/1 (100.0%)
1
heart
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 16 | C → S | 0.007299 | SNP | Missense Mutation | READ |
| 20 | C → G | 0.002427 | SNP | Missense Mutation | BLCA |
| 34 | Y → C | 0.004577 | SNP | Missense Mutation | STAD |
| 34 | Y → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 39 | F → C | 0.002288 | SNP | Missense Mutation | STAD |
| 42 | Y → C | 0.006865 | SNP | Missense Mutation | STAD |
| 68 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 107 | C → C | 0.001887 | SNP | Silent | UCEC |
| 152 | G → C | 0.002294 | SNP | Missense Mutation | OV |
| 154 | F → C | 0.007299 | SNP | Missense Mutation | READ |
| 183 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |