Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P61981 | YWHAG | 14-3-3 protein gamma (Protein kinase … | Homo sapiens (Human) | 247 aa |
Protein Details: P61981 (YWHAG)
Protein Information
| Accession | P61981 |
|---|---|
| Protein Names | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] |
| Gene Symbol | YWHAG |
| Organism | Homo sapiens (Human) |
| Length | 247 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 21076176 29733200 31251020 32944167 36430497 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MVDREQLVQK11ARLAEQAERY21DDMAAAMKNV31TELNEPLSNE41ERNLLSVAYK
51-10051NVVGARRSSW61RVISSIEQKT71SADGNEKKIE81MVRAYREKIE91KELEAVCQDV
101-150101LSLLDNYLIK111NCSETQYESK121VFYLKMKGDY131YRYLAEVATG141EKRATVVESS
151-200151EKAYSEAHEI161SKEHMQPTHP171IRLGLALNYS181VFYYEIQNAP191EQACHLAKTA
201-247201FDDAIAELDT211LNEDSYKDST221LIMQLLRDNL231TLWTSDQQDD241DGGEGNN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 97 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.76
Deep-Palm: 0.97
|
|
| 112 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.52
|
|
| 194 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.33
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.286
4
PC3
Specificity: 0.286
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.286
4/4 (100.0%)
2
LNCaP
Specificity: 0.143
2/2 (100.0%)
2
HAP1 cell
Specificity: 0.143
2/2 (100.0%)
1
Jurkat T cell
Specificity: 0.071
1/1 (100.0%)
1
DU145 cell
Specificity: 0.071
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 46 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 57 | R → C | 0.002294 | SNP | Missense Mutation | OV |
| 58 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 97 | C → S | 0.002294 | SNP | Missense Mutation | OV |
| 97* | C → ? | 0.004219 | SNP | Nonsense Mutation | SARC |