Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P62191 | PSMC1 | 26S proteasome regulatory subunit 4 … | Homo sapiens (Human) | 440 aa |
Protein Details: P62191 (PSMC1)
Protein Information
| Accession | P62191 |
|---|---|
| Protein Names | 26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1) |
| Gene Symbol | PSMC1 |
| Organism | Homo sapiens (Human) |
| Length | 440 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 25914232 29733200 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGQSQSGGHG11PGGGKKDDKD21KKKKYEPPVP31TRVGKKKKKT41KGPDAASKLP
51-10051LVTPHTQCRL61KLLKLERIKD71YLLMEEEFIR81NQEQMKPLEE91KQEEERSKVD
101-150101DLRGTPMSVG111TLEEIIDDNH121AIVSTSVGSE131HYVSILSFVD141KDLLEPGCSV
151-200151LLNHKVHAVI161GVLMDDTDPL171VTVMKVEKAP181QETYADIGGL191DNQIQEIKES
201-250201VELPLTHPEY211YEEMGIKPPK221GVILYGPPGT231GKTLLAKAVA241NQTSATFLRV
251-300251VGSELIQKYL261GDGPKLVREL271FRVAEEHAPS281IVFIDEIDAI291GTKRYDSNSG
301-350301GEREIQRTML311ELLNQLDGFD321SRGDVKVIMA331TNRIETLDPA341LIRPGRIDRK
351-400351IEFPLPDEKT361KKRIFQIHTS371RMTLADDVTL381DDLIMAKDDL391SGADIKAICT
401-440401EAGLMALRER411RMKVTNEDFK421KSKENVLYKK431QEGTPEGLYL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 58 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.97
|
|
| 148 | - | - | - |
Deep-Palm: 0.97
|
|
| 399 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
2
HAP1 cell
Specificity: 0.400
2/2 (100.0%)
1
Jurkat T cell
Specificity: 0.200
1/1 (100.0%)
1
CEM 174 cell
Specificity: 0.200
1/1 (100.0%)
1
293T cell
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 137 | S → Cfs*28 | 0.010870 | DEL | Frame Shift Del | ACC |
| 363 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 410 | R → C | 0.002288 | SNP | Missense Mutation | STAD |