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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P62736 ACTA2; ACTSA; ACTVS; GIG46 Actin, aortic smooth muscle (EC … Homo sapiens (Human) 377 aa

Protein Details: P62736 (ACTA2)

Protein Information
Accession P62736
Protein Names Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene Symbol ACTA2; ACTSA; ACTVS; GIG46
Organism Homo sapiens (Human)
Length 377 aa
Isoforms No isoforms
Related PMIDs 19137006 29733200 31251020
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.625
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
25
LNCaP cells
Specificity: 0.625
25/46 (54.3%)
10
HAP1 cells
Specificity: 0.250
10/10 (100.0%)
5
Jurkat T cells
Specificity: 0.125
5/25 (20.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MCEEEDSTAL11VCDNGSGLCK21AGFAGDDAPR31AVFPSIVGRP41RHQGVMVGMG
51-10051QKDSYVGDEA61QSKRGILTLK71YPIEHGIITN81WDDMEKIWHH91SFYNELRVAP
101-150101EEHPTLLTEA111PLNPKANREK121MTQIMFETFN131VPAMYVAIQA141VLSLYASGRT
151-200151TGIVLDSGDG161VTHNVPIYEG171YALPHAIMRL181DLAGRDLTDY191LMKILTERGY
201-250201SFVTTAEREI211VRDIKEKLCY221VALDFENEMA231TAASSSSLEK241SYELPDGQVI
251-300251TIGNERFRCP261ETLFQPSFIG271MESAGIHETT281YNSIMKCDID291IRKDLYANNV
301-350301LSGGTTMYPG311IADRMQKEIT321ALAPSTMKIK331IIAPPERKYS341VWIGGSILAS
351-377351LSTFQQMWIS361KQEYDEAGPS371IVHRKCF
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
2 Prediction (Medium) - -
219 Prediction (Low) - -
376 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
39 R → C 0.002288 SNP Missense Mutation STAD
149 R → C 0.001887 SNP Missense Mutation UCEC
267 S → C 0.003460 SNP Missense Mutation CESC
355 Q → _Q356insC*R 0.002506 INS Nonsense Mutation COAD
259* C → ? 0.002506 SNP Nonsense Mutation COAD