Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P62745 | RHOB | Rho-related GTP-binding protein RhoB (Rho … | Homo sapiens (Human) | 196 aa |
Protein Details: P62745 (RHOB)
Protein Information
| Accession | P62745 |
|---|---|
| Protein Names | Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6) |
| Gene Symbol | RHOB |
| Organism | Homo sapiens (Human) |
| Length | 196 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 31251020 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAIRKKLVV11VGDGACGKTC21LLIVFSKDEF31PEVYVPTVFE41NYVADIEVDG
51-10051KQVELALWDT61AGQEDYDRLR71PLSYPDTDVI81LMCFSVDSPD91SLENIPEKWV
101-150101PEVKHFCPNV111PIILVANKKD121LRSDEHVRTE131LARMKQEPVR141TDDGRAMAVR
151-196151IQAYDYLECS161AKTKEGVREV171FETATRAALQ181KRYGSQNGCI191NCCKVL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 16 | P-loop containing nucleoside triphosphate hydrolase Transforming protein P21 ras signature Small GTPase Small GTPase Rho | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.87
Deep-Palm: 0.98
|
|
| 20 | P-loop containing nucleoside triphosphate hydrolase Transforming protein P21 ras signature Small GTPase Small GTPase Rho | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.78
Deep-Palm: 0.98
|
|
| 83 | - | - | - |
Deep-Palm: 0.87
|
|
| 107 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.97
|
|
| 159 | SWISSPALM DBPTM CYSMODDB | Ras family |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.80
Deep-Palm: 0.96
|
| 189 | SWISSPALM DBPTM CYSMODDB | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.03
|
| 192 | SWISSPALM DBPTM CYSMODDB | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.95
Deep-Palm: 0.02
|
| 193 | SWISSPALM DBPTM CYSMODDB | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.97
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
cerebral cortex
Specificity: 0.267
4/4 (100.0%)
3
LNCaP
Specificity: 0.200
3/3 (100.0%)
1
heart
Specificity: 0.067
1/1 (100.0%)
1
HUVECs
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
Cerebral Cortex (Mass)
Specificity: 0.267
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.067
1/4 (25.0%)
1
Jurkat T cells (Mass)
Specificity: 0.067
1/10 (10.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 34 | Y → C | 0.002976 | SNP | Missense Mutation | KIRC |