Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P63261 | ACTG1 | Actin, cytoplasmic 2 (EC 3.6.4.-) … | Homo sapiens (Human) | 375 aa |
Protein Details: P63261 (ACTG1)
Protein Information
| Accession | P63261 |
|---|---|
| Protein Names | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] |
| Gene Symbol | ACTG1 |
| Organism | Homo sapiens (Human) |
| Length | 375 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 22496122 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEEEIAALVI11DNGSGMCKAG21FAGDDAPRAV31FPSIVGRPRH41QGVMVGMGQK
51-10051DSYVGDEAQS61KRGILTLKYP71IEHGIVTNWD81DMEKIWHHTF91YNELRVAPEE
101-150101HPVLLTEAPL111NPKANREKMT121QIMFETFNTP131AMYVAIQAVL141SLYASGRTTG
151-200151IVMDSGDGVT161HTVPIYEGYA171LPHAILRLDL181AGRDLTDYLM191KILTERGYSF
201-250201TTTAEREIVR211DIKEKLCYVA221LDFEQEMATA231ASSSSLEKSY241ELPDGQVITI
251-300251GNERFRCPEA261LFQPSFLGME271SCGIHETTFN281SIMKCDVDIR291KDLYANTVLS
301-350301GGTTMYPGIA311DRMQKEITAL321APSTMKIKII331APPERKYSVW341IGGSILASLS
351-375351TFQQMWISKQ361EYDESGPSIV371HRKCF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 17 | ATPase, nucleotide binding domain Actin family | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.94
|
|
| 217 | SWISSPALM DBPTM CYSMODDB | Actin |
HeLa
(29575903)
|
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.68
Deep-Palm: 0.94
|
| 257 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.70
|
|
| 272 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.14
|
|
| 285 | SWISSPALM DBPTM CYSMODDB | Actin | - |
Unknown
(32651440)
|
Deep-Palm: 0.18
|
| 374 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
cerebral cortex
Specificity: 0.308
4/4 (100.0%)
3
LNCaP
Specificity: 0.231
3/3 (100.0%)
1
Jurkat T cell
Specificity: 0.077
1/1 (100.0%)
1
EC cell
Specificity: 0.077
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.308
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 95 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 218 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 257 | C → Y | 0.001969 | SNP | Missense Mutation | HNSC |
| 293 | L → Cfs*33 | 0.002033 | DEL | Frame Shift Del | THCA |
| 335 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 337 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |