Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P68032 ACTC1 Actin, alpha cardiac muscle 1 … Homo sapiens (Human) 377 aa

Protein Details: P68032 (ACTC1)

Protein Information
AccessionP68032
Protein NamesActin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene SymbolACTC1
OrganismHomo sapiens (Human)
Length377 aa
IsoformsNo isoforms
Related PMIDs 19137006 29733200 31251020 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MCDDEETTAL11VCDNGSGLVK21AGFAGDDAPR31AVFPSIVGRP41RHQGVMVGMG
51-10051QKDSYVGDEA61QSKRGILTLK71YPIEHGIITN81WDDMEKIWHH91TFYNELRVAP
101-150101EEHPTLLTEA111PLNPKANREK121MTQIMFETFN131VPAMYVAIQA141VLSLYASGRT
151-200151TGIVLDSGDG161VTHNVPIYEG171YALPHAIMRL181DLAGRDLTDY191LMKILTERGY
201-250201SFVTTAEREI211VRDIKEKLCY221VALDFENEMA231TAASSSSLEK241SYELPDGQVI
251-300251TIGNERFRCP261ETLFQPSFIG271MESAGIHETT281YNSIMKCDID291IRKDLYANNV
301-350301LSGGTTMYPG311IADRMQKEIT321ALAPSTMKIK331IIAPPERKYS341VWIGGSILAS
351-377351LSTFQQMWIS361KQEYDEAGPS371IVHRKCF
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
2 - - -
GPS-Palm: 0.89
Deep-Palm: 0.02
12 ATPase, nucleotide binding domain Actin family - -
Deep-Palm: 0.14
219 - - -
GPS-Palm: 0.71
Deep-Palm: 0.91
259 - - -
Deep-Palm: 0.65
287 - - -
Deep-Palm: 0.33
376 - - -
GPS-Palm: 0.96
Deep-Palm: 0.02
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
2
LNCaP
Specificity: 0.286
2/2 (100.0%)
1
Jurkat T cell
Specificity: 0.143
1/1 (100.0%)
1
293T cell
Specificity: 0.143
1/1 (100.0%)
1
cerebral cortex
Specificity: 0.143
1/1 (100.0%)
1
heart
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.143
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
15 G → C 0.001969 SNP Missense Mutation HNSC
30 R → C 0.003460 SNP Missense Mutation CESC
38 G → C 0.002033 SNP Missense Mutation LUSC
39 R → C 0.001764 SNP Missense Mutation LUAD
39 R → C 0.003460 SNP Missense Mutation CESC
93 Y → C 0.002033 SNP Missense Mutation LUSC
149 R → C 0.002033 SNP Missense Mutation LUSC
212 R → C 0.002506 SNP Missense Mutation COAD
212 R → C 0.001887 SNP Missense Mutation UCEC
256 R → C 0.002506 SNP Missense Mutation COAD
314 R → C 0.006424 SNP Missense Mutation SKCM
337 R → C 0.019608 SNP Missense Mutation CHOL
358 W → C 0.001969 SNP Missense Mutation HNSC
370 S → C 0.002288 SNP Missense Mutation STAD