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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P68133 ACTA1; ACTA Actin, alpha skeletal muscle (EC … Homo sapiens (Human) 377 aa

Protein Details: P68133 (ACTA1)

Protein Information
Accession P68133
Protein Names Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]
Gene Symbol ACTA1; ACTA
Organism Homo sapiens (Human)
Length 377 aa
Isoforms No isoforms
Related PMIDs 19137006 21076176 31251020 32944167 33636221 36430497
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.625
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
25
LNCaP cells
Specificity: 0.625
25/46 (54.3%)
11
Jurkat T cells
Specificity: 0.275
11/25 (44.0%)
2
PC3 cells
Specificity: 0.050
2/4 (50.0%)
1
Cerebral cortex
Specificity: 0.025
1/4 (25.0%)
1
Liver membrane
Specificity: 0.025
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MCDEDETTAL11VCDNGSGLVK21AGFAGDDAPR31AVFPSIVGRP41RHQGVMVGMG
51-10051QKDSYVGDEA61QSKRGILTLK71YPIEHGIITN81WDDMEKIWHH91TFYNELRVAP
101-150101EEHPTLLTEA111PLNPKANREK121MTQIMFETFN131VPAMYVAIQA141VLSLYASGRT
151-200151TGIVLDSGDG161VTHNVPIYEG171YALPHAIMRL181DLAGRDLTDY191LMKILTERGY
201-250201SFVTTAEREI211VRDIKEKLCY221VALDFENEMA231TAASSSSLEK241SYELPDGQVI
251-300251TIGNERFRCP261ETLFQPSFIG271MESAGIHETT281YNSIMKCDID291IRKDLYANNV
301-350301MSGGTTMYPG311IADRMQKEIT321ALAPSTMKIK331IIAPPERKYS341VWIGGSILAS
351-377351LSTFQQMWIT361KQEYDEAGPS371IVHRKCF
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
2 Prediction (Medium) - -
219 Prediction (Low) - -
376 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
39 R → C 0.001969 SNP Missense Mutation HNSC
50 G → C 0.002294 SNP Missense Mutation OV
97 R → C 0.002141 SNP Missense Mutation SKCM
179 R → C 0.001887 SNP Missense Mutation UCEC
198 R → C 0.002288 SNP Missense Mutation STAD
198 R → C 0.001887 SNP Missense Mutation UCEC
258 R → C 0.002427 SNP Missense Mutation BLCA
275 G → C 0.001764 SNP Missense Mutation LUAD
? ? → ? 0.001887 SNP Silent UCEC