Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P68133 | ACTA1 | Actin, alpha skeletal muscle (EC … | Homo sapiens (Human) | 377 aa |
Protein Details: P68133 (ACTA1)
Protein Information
| Accession | P68133 |
|---|---|
| Protein Names | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] |
| Gene Symbol | ACTA1 |
| Organism | Homo sapiens (Human) |
| Length | 377 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 21076176 22496122 31251020 32944167 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MCDEDETTAL11VCDNGSGLVK21AGFAGDDAPR31AVFPSIVGRP41RHQGVMVGMG
51-10051QKDSYVGDEA61QSKRGILTLK71YPIEHGIITN81WDDMEKIWHH91TFYNELRVAP
101-150101EEHPTLLTEA111PLNPKANREK121MTQIMFETFN131VPAMYVAIQA141VLSLYASGRT
151-200151TGIVLDSGDG161VTHNVPIYEG171YALPHAIMRL181DLAGRDLTDY191LMKILTERGY
201-250201SFVTTAEREI211VRDIKEKLCY221VALDFENEMA231TAASSSSLEK241SYELPDGQVI
251-300251TIGNERFRCP261ETLFQPSFIG271MESAGIHETT281YNSIMKCDID291IRKDLYANNV
301-350301MSGGTTMYPG311IADRMQKEIT321ALAPSTMKIK331IIAPPERKYS341VWIGGSILAS
351-377351LSTFQQMWIT361KQEYDEAGPS371IVHRKCF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 2 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.01
|
|
| 12 | ATPase, nucleotide binding domain Actin family | - | - |
Deep-Palm: 0.13
|
|
| 219 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.91
|
|
| 259 | - | - | - |
Deep-Palm: 0.65
|
|
| 287 | - | - | - |
Deep-Palm: 0.13
|
|
| 376 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.222
2
LNCaP
Specificity: 0.200
2/2 (100.0%)
2
Jurkat T cell
Specificity: 0.200
2/2 (100.0%)
2
PC3
Specificity: 0.200
2/2 (100.0%)
1
EC cell
Specificity: 0.100
1/1 (100.0%)
1
cerebral cortex
Specificity: 0.100
1/1 (100.0%)
1
heart
Specificity: 0.100
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.100
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 39 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 50 | G → C | 0.002294 | SNP | Missense Mutation | OV |
| 97 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 179 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 198 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 198 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 258 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 275 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| ? | ? → ? | 0.001887 | SNP | Silent | UCEC |