Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P68371 | TUBB4B; TUBB2C | Tubulin beta-4B chain (Tubulin beta-2 … | Homo sapiens (Human) | 445 aa |
Protein Details: P68371 (TUBB4B)
Protein Information
| Accession | P68371 |
|---|---|
| Protein Names | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) |
| Gene Symbol | TUBB4B; TUBB2C |
| Organism | Homo sapiens (Human) |
| Length | 445 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 32944167 36430497 37611173 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.636
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
35
LNCaP cells
Specificity: 0.636
35/46 (76.1%)
10
HAP1 cells
Specificity: 0.182
10/10 (100.0%)
4
PC3 cells
Specificity: 0.073
4/4 (100.0%)
4
293T cells
Specificity: 0.073
4/10 (40.0%)
1
U937 cells
Specificity: 0.018
1/1 (100.0%)
1
Cerebral cortex
Specificity: 0.018
1/4 (25.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MREIVHLQAG11QCGNQIGAKF21WEVISDEHGI31DPTGTYHGDS41DLQLERINVY
51-10051YNEATGGKYV61PRAVLVDLEP71GTMDSVRSGP81FGQIFRPDNF91VFGQSGAGNN
101-150101WAKGHYTEGA111ELVDSVLDVV121RKEAESCDCL131QGFQLTHSLG141GGTGSGMGTL
151-200151LISKIREEYP161DRIMNTFSVV171PSPKVSDTVV181EPYNATLSVH191QLVENTDETY
201-250201CIDNEALYDI211CFRTLKLTTP221TYGDLNHLVS231ATMSGVTTCL241RFPGQLNADL
251-300251RKLAVNMVPF261PRLHFFMPGF271APLTSRGSQQ281YRALTVPELT291QQMFDAKNMM
301-350301AACDPRHGRY311LTVAAVFRGR321MSMKEVDEQM331LNVQNKNSSY341FVEWIPNNVK
351-400351TAVCDIPPRG361LKMSATFIGN371STAIQELFKR381ISEQFTAMFR391RKAFLHWYTG
401-445401EGMDEMEFTE411AESNMNDLVS421EYQQYQDATA431EEEGEFEEEA441EEEVA
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 12 | Prediction (Low) | - | - |
| 127 | Prediction (Low) | - | - |
| 211 | Prediction (Medium) | - | - |
| 239 | Prediction (High) | - | - |
| 303 | Prediction (High) | - | - |
| 354 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) | Tubulin C-terminal domain | 37611173 |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 51 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |