Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P78368 | CSNK1G2 | Casein kinase I isoform gamma-2 … | Homo sapiens (Human) | 415 aa |
Protein Details: P78368 (CSNK1G2)
Protein Information
| Accession | P78368 |
|---|---|
| Protein Names | Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) |
| Gene Symbol | CSNK1G2 |
| Organism | Homo sapiens (Human) |
| Length | 415 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 29733200 31251020 33636221 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MDFDKKGGKG11ETEEGRRMSK21AGGGRSSHGI31RSSGTSSGVL41MVGPNFRVGK
51-10051KIGCGNFGEL61RLGKNLYTNE71YVAIKLEPIK81SRAPQLHLEY91RFYKQLSATE
101-150101GVPQVYYFGP111CGKYNAMVLE121LLGPSLEDLF131DLCDRTFTLK141TVLMIAIQLI
151-200151TRMEYVHTKS161LIYRDVKPEN171FLVGRPGTKR181QHAIHIIDFG191LAKEYIDPET
201-250201KKHIPYREHK211SLTGTARYMS221INTHLGKEQS231RRDDLEALGH241MFMYFLRGSL
251-300251PWQGLKADTL261KERYQKIGDT271KRATPIEVLC281ENFPEEMATY291LRYVRRLDFF
301-350301EKPDYDYLRK311LFTDLFDRSG321FVFDYEYDWA331GKPLPTPIGT341VHTDLPSQPQ
351-400351LRDKTQPHSK361NQALNSTNGE371LNADDPTAGH381SNAPITAPAE391VEVADETKCC
401-415401CFFKRRKRKS411LQRHK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 54 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.93
|
|
| 111 | - | - | - |
Deep-Palm: 0.95
|
|
| 133 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.97
|
|
| 280 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.86
|
|
| 399 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.94
|
|
| 400 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.94
|
|
| 401 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.308
4
Primary T cell
Specificity: 0.267
4/4 (100.0%)
4
Jurkat T cell
Specificity: 0.267
4/4 (100.0%)
3
LNCaP
Specificity: 0.200
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.067
1/1 (100.0%)
1
heart
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
LNCaP cells (Mass)
Specificity: 0.067
1/4 (25.0%)
1
Cerebral Cortex (Mass)
Specificity: 0.067
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 22 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 47 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 47 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 55 | G → C | 0.002288 | SNP | Missense Mutation | STAD |
| 175 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 296 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 305 | Y → C | 0.001969 | SNP | Missense Mutation | LGG |