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UniProt ID Gene Symbol Protein Name Organism Length Action
P80365 HSD11B2; HSD11K; SDR9C3 11-beta-hydroxysteroid dehydrogenase type 2 (11-DH2) … Homo sapiens (Human) 405 aa

Protein Details: P80365 (HSD11B2)

Protein Information
Accession P80365
Protein Names 11-beta-hydroxysteroid dehydrogenase type 2 (11-DH2) (11-beta-HSD2) (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type II) (11-HSD type II) (11-beta-HSD type II) (Corticosteroid 11-beta-dehydrogenase isozyme 2) (NAD-dependent 11-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 3)
Gene Symbol HSD11B2; HSD11K; SDR9C3
Organism Homo sapiens (Human)
Length 405 aa
Isoforms No isoforms
Related PMIDs 31251020
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
12
LNCaP cells
Specificity: 1.000
12/46 (26.1%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MERWPWPSGG11AWLLVAARAL21LQLLRSDLRL31GRPLLAALAL41LAALDWLCQR
51-10051LLPPPAALAV61LAAAGWIALS71RLARPQRLPV81ATRAVLITGC91DSGFGKETAK
101-150101KLDSMGFTVL111ATVLELNSPG121AIELRTCCSP131RLRLLQMDLT141KPGDISRVLE
151-200151FTKAHTTSTG161LWGLVNNAGH171NEVVADAELS181PVATFRSCME191VNFFGALELT
201-250201KGLLPLLRSS211RGRIVTVGSP221AGDMPYPCLG231AYGTSKAAVA241LLMDTFSCEL
251-300251LPWGVKVSII261QPGCFKTESV271RNVGQWEKRK281QLLLANLPQE291LLQAYGKDYI
301-350301EHLHGQFLHS311LRLAMSDLTP321VVDAITDALL331AARPRRRYYP341GQGLGLMYFI
351-400351HYYLPEGLRR361RFLQAFFISH371CLPRALQPGQ381PGTTPPQDAA391QDPNLSPGPS
401-405401PAVAR
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
48 Prediction (High) - -
90 Prediction (High) - -
127 Prediction (Medium) - -
128 Prediction (High) - -
264 Prediction (High) - -
371 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
312 R → C 0.002288 SNP Missense Mutation STAD
335 R → C 0.001969 SNP Missense Mutation HNSC