Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P80365 | HSD11B2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-DH2) … | Homo sapiens (Human) | 405 aa |
Protein Details: P80365 (HSD11B2)
Protein Information
| Accession | P80365 |
|---|---|
| Protein Names | 11-beta-hydroxysteroid dehydrogenase type 2 (11-DH2) (11-beta-HSD2) (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type II) (11-HSD type II) (11-beta-HSD type II) (Corticosteroid 11-beta-dehydrogenase isozyme 2) (NAD-dependent 11-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 3) |
| Gene Symbol | HSD11B2 |
| Organism | Homo sapiens (Human) |
| Length | 405 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MERWPWPSGG11AWLLVAARAL21LQLLRSDLRL31GRPLLAALAL41LAALDWLCQR
51-10051LLPPPAALAV61LAAAGWIALS71RLARPQRLPV81ATRAVLITGC91DSGFGKETAK
101-150101KLDSMGFTVL111ATVLELNSPG121AIELRTCCSP131RLRLLQMDLT141KPGDISRVLE
151-200151FTKAHTTSTG161LWGLVNNAGH171NEVVADAELS181PVATFRSCME191VNFFGALELT
201-250201KGLLPLLRSS211RGRIVTVGSP221AGDMPYPCLG231AYGTSKAAVA241LLMDTFSCEL
251-300251LPWGVKVSII261QPGCFKTESV271RNVGQWEKRK281QLLLANLPQE291LLQAYGKDYI
301-350301EHLHGQFLHS311LRLAMSDLTP321VVDAITDALL331AARPRRRYYP341GQGLGLMYFI
351-400351HYYLPEGLRR361RFLQAFFISH371CLPRALQPGQ381PGTTPPQDAA391QDPNLSPGPS
401-405401PAVAR
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 48 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.99
|
|
| 90 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.97
|
|
| 127 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.97
|
|
| 128 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.98
|
|
| 188 | - | - | - |
Deep-Palm: 0.98
|
|
| 228 | - | - | - |
Deep-Palm: 0.97
|
|
| 248 | - | - | - |
Deep-Palm: 0.97
|
|
| 264 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.97
|
|
| 371 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.93
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 312 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 335 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |