Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P97494 | Gclc | Glutamate--cysteine ligase catalytic subunit (EC … | Mus musculus (Mouse) | 637 aa |
Protein Details: P97494 (Gclc)
Protein Information
| Accession | P97494 |
|---|---|
| Protein Names | Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) |
| Gene Symbol | Gclc |
| Organism | Mus musculus (Mouse) |
| Length | 637 aa |
| Isoforms | No isoforms |
| Related PMIDs | 28526873 35358180 35477839 37925639 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGLLSQGSPL11SWEETQRHAD21HVRRHGILQF31LHIYHAVKDR41HKDVLKWGDE
51-10051VEYMLVSFDH61ENRKVQLLLN71GGDVLETLQE81KGERTNPNHP91TLWRPEYGSY
101-150101MIEGTPGQPY111GGTMSEFNTV121EANMRKRRKE131ATSVLGEHQA141LCTITSFPRL
151-200151GCPGFTLPEH161RPNPEEGGAS171KSLFFPDEAI181NKHPRFGTLT191RNIRHRRGEK
201-250201VVINVPIFKD211KNTPSPFVET221FPEDAEASKA231SQPDHIYMDA241MGFGMGNCCL
251-300251QVTFQACSIS261EARYLYDQLA271TICPIVMALS281AASPFYRGYV291SDIDCRWGVI
301-350301SASVDDRTRE311ERGLEPLKNN321RFRISKSRYD331SIDSYLSKCG341EKYNDIDLTI
351-400351DKEIYEQLLE361EGIDHLLAQH371VAHLFIRDPL381TLFEEKIHLD391DANESDHFEN
401-450401IQSTNWQTMR411FKPPPPNSDI421GWRVEFRPME431VQLTDFENSA441YVVFVVLLTR
451-500451VILSYKLDFL461IPLSKVDENM471KVAQKRDAVL481QGMFYFRKDI491CKGGNAVVDG
501-550501CSKAQSSSEP511AAEEYTLMSI521DTIINGKEGV531FPGLIPILNS541YLENMEVDVD
551-600551TRCSILNYLK561LIKKRASGEL571MTVARWMREF581IANHPDYKQD591SVITDEINYS
601-637601LIWKCNQIAD611ELCECPELLG621SGFRKAKYSG631GKSDPSA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 142 | - | - | - |
Deep-Palm: 0.95
|
|
| 152 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.75
|
|
| 248 | - | - | - |
Deep-Palm: 0.03
|
|
| 249 | - | - | - |
Deep-Palm: 0.03
|
|
| 257 | - | - | - |
Deep-Palm: 0.42
|
|
| 273 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.87
|
|
| 295 | SWISSPALM DBPTM CYSMODDB | Glutamate-cysteine ligase |
Liver
(28526873)
| - |
Deep-Palm: 0.82
|
| 339 | - | - | - |
Deep-Palm: 0.58
|
|
| 491 | - | - | - |
Deep-Palm: 0.65
|
|
| 501 | - | - | - |
Deep-Palm: 0.78
|
|
| 553 | - | - | - |
Deep-Palm: 0.96
|
|
| 605 | - | - | - |
Deep-Palm: 0.25
|
|
| 613 | - | - | - |
Deep-Palm: 0.59
|
|
| 615 | - | - | - |
Deep-Palm: 0.82
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
Liver
Specificity: 0.571
4/4 (100.0%)
2
Testis
Specificity: 0.286
2/2 (100.0%)
1
Brain
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.