Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q01970 | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC … | Homo sapiens (Human) | 1234 aa |
Protein Details: Q01970 (PLCB3)
Protein Information
| Accession | Q01970 |
|---|---|
| Protein Names | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) |
| Gene Symbol | PLCB3 |
| Organism | Homo sapiens (Human) |
| Length | 1234 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31382980 32944167 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAGAQPGVHA11LQLEPPTVVE21TLRRGSKFIK31WDEETSSRNL41VTLRVDPNGF
51-10051FLYWTGPNME61VDTLDISSIR71DTRTGRYARL81PKDPKIREVL91GFGGPDARLE
101-150101EKLMTVVSGP111DPVNTVFLNF121MAVQDDTAKV131WSEELFKLAM141NILAQNASRN
151-200151TFLRKAYTKL161KLQVNQDGRI171PVKNILKMFS181ADKKRVETAL191ESCGLKFNRS
201-250201ESIRPDEFSL211EIFERFLNKL221CLRPDIDKIL231LEIGAKGKPY241LTLEQLMDFI
251-300251NQKQRDPRLN261EVLYPPLRPS271QARLLIEKYE281PNQQFLERDQ291MSMEGFSRYL
301-350301GGEENGILPL311EALDLSTDMT321QPLSAYFINS331SHNTYLTAGQ341LAGTSSVEMY
351-400351RQALLWGCRC361VELDVWKGRP371PEEEPFITHG381FTMTTEVPLR391DVLEAIAETA
401-450401FKTSPYPVIL411SFENHVDSAK421QQAKMAEYCR431SIFGDALLIE441PLDKYPLAPG
451-500451VPLPSPQDLM461GRILVKNKKR471HRPSAGGPDS481AGRKRPLEQS491NSALSESSAA
501-550501TEPSSPQLGS511PSSDSCPGLS521NGEEVGLEKP531SLEPQKSLGD541EGLNRGPYVL
551-600551GPADREDEEE561DEEEEEQTDP571KKPTTDEGTA581SSEVNATEEM591STLVNYIEPV
601-650601KFKSFEAARK611RNKCFEMSSF621VETKAMEQLT631KSPMEFVEYN641KQQLSRIYPK
651-700651GTRVDSSNYM661PQLFWNVGCQ671LVALNFQTLD681VAMQLNAGVF691EYNGRSGYLL
701-750701KPEFMRRPDK711SFDPFTEVIV721DGIVANALRV731KVISGQFLSD741RKVGIYVEVD
751-800751MFGLPVDTRR761KYRTRTSQGN771SFNPVWDEEP781FDFPKVVLPT791LASLRIAAFE
801-850801EGGKFVGHRI811LPVSAIRSGY821HYVCLRNEAN831QPLCLPALLI841YTEASDYIPD
851-900851DHQDYAEALI861NPIKHVSLMD871QRARQLAALI881GESEAQAGQE891TCQDTQSQQL
901-950901GSQPSSNPTP911SPLDASPRRP921PGPTTSPAST931SLSSPGQRDD941LIASILSEVA
951-1000951PTPLDELRGH961KALVKLRSRQ971ERDLRELRKK981HQRKAVTLTR991RLLDGLAQAQ
1001-10501001AEGRCRLRPG1011ALGGAADVED1021TKEGEDEAKR1031YQEFQNRQVQ1041SLLELREAQV
1051-11001051DAEAQRRLEH1061LRQALQRLRE1071VVLDANTTQF1081KRLKEMNERE1091KKELQKILDR
1101-11501101KRHNSISEAK1111MRDKHKKEAE1121LTEINRRHIT1131ESVNSIRRLE1141EAQKQRHDRL
1151-12001151VAGQQQVLQQ1161LAEEEPKLLA1171QLAQECQEQR1181ARLPQEIRRS1191LLGEMPEGLG
1201-12341201DGPLVACASN1211GHAPGSSGHL1221SGADSESQEE1231NTQL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 193 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.96
|
|
| 221 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.98
|
|
| 358 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.64
|
|
| 360 | - | - | - |
Deep-Palm: 0.70
|
|
| 429 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.85
|
|
| 516 | - | - | - |
Deep-Palm: 0.96
|
|
| 614 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.58
|
|
| 669 | - | - | - |
Deep-Palm: 0.24
|
|
| 824 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.91
|
|
| 834 | - | - | - |
Deep-Palm: 0.71
|
|
| 892 | - | - | - |
Deep-Palm: 0.82
|
|
| 1005 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.98
|
|
| 1176 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.98
|
|
| 1207 | - | - | - |
Deep-Palm: 0.93
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
2
PC3
Specificity: 0.667
2/2 (100.0%)
1
U937 cell
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 44 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 44 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 213 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 335 | Y → C | 0.002294 | SNP | Missense Mutation | OV |
| 360 | C → C | 0.002288 | SNP | Silent | STAD |
| 390 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 430 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 518 | G → C | 0.001969 | SNP | Missense Mutation | LGG |
| 695 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 695 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 795 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |