Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q02218-3 | OGDH | 2-oxoglutarate dehydrogenase complex component E1 … | Homo sapiens (Human) | 427 aa |
Protein Details: Q02218-3 (OGDH)
Protein Information
| Accession | Q02218-3 |
|---|---|
| Protein Names | 2-oxoglutarate dehydrogenase complex component E1 (E1o) (HsOGDH) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) |
| Gene Symbol | OGDH |
| Organism | Homo sapiens (Human) |
| Length | 427 aa |
| Isoforms | |
| Related PMIDs | 31251020 36430497 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MFHLRTCAAK11LRPLTASQTV21KTFSQNRPAA31ARTFQQIRCY41SAPVAAEPFL
51-10051SGTSSNYVEE61MYCAWLENPK71SVHKSWDIFF81RNTNAGAPPG91TAYQSPLPLS
101-150101RGSLAAVAHA111QSLVEAQPNV121DKLVEDHLAV131QSLIRAYQIR141GHHVAQLDPL
151-200151GILDADLDSS161VPADIISSTD171KLGFYGLDES181DLDKVFHLPT191TTFIGGQESA
201-250201LPLREIIRRL211EMAYCQHIGV221EFMFINDLEQ231CQWIRQKFET241PGIMQFTNEE
251-300251KRTLLARLVR261STRFEEFLQR271KWSSEKRFGL281EGCEVLIPAL291KTIIDKSSEN
301-350301GVDYVIMGMP311HRGRLNVLAN321VIRKELEQIF331CQFDSKLEAA341DEGSGDVKYH
351-400351LGMYHRRINR361VTDRNITLSL371VANPSHLEAA381DPVVMGKTKA391EQFYCGDTEG
401-427401KKVRPRERRA411RQIVKAPCSS421MEFRSPT
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 7 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.06
|
|
| 39 | - | - | - |
Deep-Palm: 0.81
|
|
| 63 | - | - | - |
Deep-Palm: 0.09
|
|
| 215 | - | - | - |
Deep-Palm: 0.70
|
|
| 231 | - | - | - |
Deep-Palm: 0.05
|
|
| 283 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.97
|
|
| 331 | - | - | - |
Deep-Palm: 0.93
|
|
| 395 | - | - | - |
Deep-Palm: 0.91
|
|
| 487 | - | - | - |
Deep-Palm: 0.11
|
|
| 507 | - | - | - |
Deep-Palm: 0.38
|
|
| 566 | - | - | - |
Deep-Palm: 0.62
|
|
| 604 | - | - | - |
Deep-Palm: 0.77
|
|
| 700 | - | - | - |
Deep-Palm: 0.04
|
|
| 716 | - | - | - |
Deep-Palm: 0.58
|
|
| 756 | - | - | - |
Deep-Palm: 0.11
|
|
| 763 | - | - | - |
Deep-Palm: 0.10
|
|
| 802 | - | - | - |
Deep-Palm: 0.86
|
|
| 825 | - | - | - |
Deep-Palm: 0.06
|
|
| 832 | - | - | - |
Deep-Palm: 0.09
|
|
| 904 | - | - | - |
Deep-Palm: 0.96
|
|
| 956 | - | - | - |
Deep-Palm: 0.80
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
cerebral cortex
Specificity: 0.571
4/4 (100.0%)
3
LNCaP
Specificity: 0.429
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 41 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 81 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 81 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 277 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 283 | C → C | 0.001887 | SNP | Silent | UCEC |
| 604 | C → C | 0.001764 | SNP | Silent | LUAD |
| 653 | W → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 686 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 700 | C → S | 0.001764 | SNP | Missense Mutation | LUAD |
| 713 | Y → C | 0.002976 | SNP | Missense Mutation | KIRC |
| 769 | W → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 794 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 864 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 904 | C → C | 0.001969 | SNP | Silent | LGG |
| 909 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |