Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q02543 | RPL18A | Large ribosomal subunit protein eL20 … | Homo sapiens (Human) | 176 aa |
Protein Details: Q02543 (RPL18A)
Protein Information
| Accession | Q02543 |
|---|---|
| Protein Names | Large ribosomal subunit protein eL20 (60S ribosomal protein L18a) |
| Gene Symbol | RPL18A |
| Organism | Homo sapiens (Human) |
| Length | 176 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MKASGTLREY11KVVGRCLPTP21KCHTPPLYRM31RIFAPNHVVA41KSRFWYFVSQ
51-10051LKKMKKSSGE61IVYCGQVFEK71SPLRVKNFGI81WLRYDSRSGT91HNMYREYRDL
101-150101TTAGAVTQCY111RDMGARHRAR121AHSIQIMKVE131EIAASKCRRP141AVKQFHDSKI
151-176151KFPLPHRVLR161RQHKPRFTTK171RPNTFF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 16 | Large ribosomal subunit protein eL20, eukaryotes Large ribosomal subunit protein eL20 | - | - |
Deep-Palm: 0.87
|
|
| 22 | Large ribosomal subunit protein eL20, eukaryotes Large ribosomal subunit protein eL20 | - | - |
Deep-Palm: 0.51
|
|
| 64 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.85
Deep-Palm: 0.94
|
|
| 109 | SWISSPALM DBPTM CYSMODDB | Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.96
Deep-Palm: 0.91
|
| 137 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.47
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.429
3
LNCaP
Specificity: 0.250
3/3 (100.0%)
2
cerebral cortex
Specificity: 0.167
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.083
1/1 (100.0%)
1
293T cell
Specificity: 0.083
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.333
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.083
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 29 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 43 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 63 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 83 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 83 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 166 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 109* | C → ? | 0.005618 | SNP | Nonsense Mutation | PAAD |