Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q02790 | FKBP4 | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase … | Homo sapiens (Human) | 459 aa |
Protein Details: Q02790 (FKBP4)
Protein Information
| Accession | Q02790 |
|---|---|
| Protein Names | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] |
| Gene Symbol | FKBP4 |
| Organism | Homo sapiens (Human) |
| Length | 459 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31382980 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MTAEEMKATE11SGAQSAPLPM21EGVDISPKQD31EGVLKVIKRE41GTGTEMPMIG
51-10051DRVFVHYTGW61LLDGTKFDSS71LDRKDKFSFD81LGKGEVIKAW91DIAIATMKVG
101-150101EVCHITCKPE111YAYGSAGSPP121KIPPNATLVF131EVELFEFKGE141DLTEEEDGGI
151-200151IRRIQTRGEG161YAKPNEGAIV171EVALEGYYKD181KLFDQRELRF191EIGEGENLDL
201-250201PYGLERAIQR211MEKGEHSIVY221LKPSYAFGSV231GKEKFQIPPN241AELKYELHLK
251-300251SFEKAKESWE261MNSEEKLEQS271TIVKERGTVY281FKEGKYKQAL291LQYKKIVSWL
301-350301EYESSFSNEE311AQKAQALRLA321SHLNLAMCHL331KLQAFSAAIE341SCNKALELDS
351-400351NNEKGLFRRG361EAHLAVNDFE371LARADFQKVL381QLYPNNKAAK391TQLAVCQQRI
401-450401RRQLAREKKL411YANMFERLAE421EENKAKAEAS431SGDHPTDTEM441KEEQKSNTAG
451-459451SQSQVETEA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 103 | - | - | - |
Deep-Palm: 0.69
|
|
| 107 | - | - | - |
Deep-Palm: 0.59
|
|
| 328 | - | - | - |
Deep-Palm: 0.95
|
|
| 342 | SWISSPALM DBPTM CYSMODDB | Tetratricopeptide repeat |
SW480 cell line
(26865113)
| - |
GPS-Palm: 0.87
Deep-Palm: 0.89
|
| 396 | - |
SW480 cell line
(26865113)
| - |
GPS-Palm: 0.97
Deep-Palm: 0.89
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
2
PC3
Specificity: 0.400
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.200
1/1 (100.0%)
1
U937 cell
Specificity: 0.200
1/1 (100.0%)
1
293T cell
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 152 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 157 | R → C | 0.004219 | SNP | Missense Mutation | SARC |
| 157 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 383 | Y → C | 0.010870 | SNP | Missense Mutation | ACC |