Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q02790 | FKBP4; FKBP52 | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase … | Homo sapiens (Human) | 459 aa |
Protein Details: Q02790 (FKBP4)
Protein Information
| Accession | Q02790 |
|---|---|
| Protein Names | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] |
| Gene Symbol | FKBP4; FKBP52 |
| Organism | Homo sapiens (Human) |
| Length | 459 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.556
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
10
HAP1 cells
Specificity: 0.556
10/10 (100.0%)
4
293T cells
Specificity: 0.222
4/10 (40.0%)
2
PC3 cells
Specificity: 0.111
2/4 (50.0%)
1
U937 cells
Specificity: 0.056
1/1 (100.0%)
1
LNCaP cells
Specificity: 0.056
1/46 (2.2%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MTAEEMKATE11SGAQSAPLPM21EGVDISPKQD31EGVLKVIKRE41GTGTEMPMIG
51-10051DRVFVHYTGW61LLDGTKFDSS71LDRKDKFSFD81LGKGEVIKAW91DIAIATMKVG
101-150101EVCHITCKPE111YAYGSAGSPP121KIPPNATLVF131EVELFEFKGE141DLTEEEDGGI
151-200151IRRIQTRGEG161YAKPNEGAIV171EVALEGYYKD181KLFDQRELRF191EIGEGENLDL
201-250201PYGLERAIQR211MEKGEHSIVY221LKPSYAFGSV231GKEKFQIPPN241AELKYELHLK
251-300251SFEKAKESWE261MNSEEKLEQS271TIVKERGTVY281FKEGKYKQAL291LQYKKIVSWL
301-350301EYESSFSNEE311AQKAQALRLA321SHLNLAMCHL331KLQAFSAAIE341SCNKALELDS
351-400351NNEKGLFRRG361EAHLAVNDFE371LARADFQKVL381QLYPNNKAAK391TQLAVCQQRI
401-450401RRQLAREKKL411YANMFERLAE421EENKAKAEAS431SGDHPTDTEM441KEEQKSNTAG
451-459451SQSQVETEA
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 342 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | Tetratricopeptide repeat | - |
| 396 | Prediction (High) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 152 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 157 | R → C | 0.004219 | SNP | Missense Mutation | SARC |
| 157 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 383 | Y → C | 0.010870 | SNP | Missense Mutation | ACC |