Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q02952-2 | AKAP12 | A-kinase anchor protein 12 (AKAP-12) … | Homo sapiens (Human) | 1684 aa |
Protein Details: Q02952-2 (AKAP12)
Protein Information
| Accession | Q02952-2 |
|---|---|
| Protein Names | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) |
| Gene Symbol | AKAP12 |
| Organism | Homo sapiens (Human) |
| Length | 1684 aa |
| Isoforms | |
| Related PMIDs | 29575903 32944167 36430497 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLGTITITVG11QRDSEDVSKR21DSDKEMATKS31AVVHDITDDG41QEETPEIIEQ
51-10051IPSSESNLEE61LTQPTESQAN71DIGFKKVFKF81VGFKFTVKKD91KTEKPDTVQL
101-150101LTVKKDEGEG111AAGAGDHKDP121SLGAGEAASK131ESEPKQSTEK141PEETLKREQS
151-200151HAEISPPAES161GQAVEECKEE171GEEKQEKEPS181KSAESPTSPV191TSETGSTFKK
201-250201FFTQGWAGWR211KKTSFRKPKE221DEVEASEKKK231EQEPEKVDTE241EDGKAEVASE
251-300251KLTASEQAHP261QEPAESAHEP271RLSAEYEKVE281LPSEEQVSGS291QGPSEEKPAP
301-350301LATEVFDEKI311EVHQEEVVAE321VHVSTVEERT331EEQKTEVEET341AGSVPAEELV
351-400351EMDAEPQEAE361PAKELVKLKE371TCVSGEDPTQ381GADLSPDEKV391LSKPPEGVVS
401-450401EVEMLSSQER411MKVQGSPLKK421LFTSTGLKKL431SGKKQKGKRG441GGDEESGEHT
451-500451QVPADSPDSQ461EEQKGESSAS471SPEEPEEITC481LEKGLAEVQQ491DGEAEEGATS
501-550501DGEKKREGVT511PWASFKKMVT521PKKRVRRPSE531SDKEDELDKV541KSATLSSTES
551-600551TASEMQEEMK561GSVEEPKPEE571PKRKVDTSVS581WEALICVGSS591KKRARRGSSS
601-650601DEEGGPKAMG611GDHQKADEAG621KDKETGTDGI631LAGSQEHDPG641QGSSSPEQAG
651-700651SPTEGEGVST661WESFKRLVTP671RKKSKSKLEE681KSEDSIAGSG691VEHSTPDTEP
701-750701GKEESWVSIK711KFIPGRRKKR721PDGKQEQAPV731EDAGPTGANE741DDSDVPAVVP
751-800751LSEYDAVERE761KMEAQQAQKS771AEQPEQKAAT781EVSKELSESQ791VHMMAAAVAD
801-850801GTRAATIIEE811RSPSWISASV821TEPLEQVEAE831AALLTEEVLE841REVIAEEEPP
851-900851TVTEPLPENR861EARGDTVVSE871AELTPEAVTA881AETAGPLGAE891EGTEASAAEE
901-950901TTEMVSAVSQ911LTDSPDTTEE921ATPVQEVEGG931VPDIEEQERR941TQEVLQAVAE
951-1000951KVKEESQLPG961TGGPEDVLQP971VQRAEAERPE981EQAEASGLKK991ETDVVLKVDA
1001-10501001QEAKTEPFTQ1011GKVVGQTTPE1021SFEKAPQVTE1031SIESSELVTT1041CQAETLAGVK
1051-11001051SQEMVMEQAI1061PPDSVETPTD1071SETDGSTPVA1081DFDAPGTTQK1091DEIVEIHEEN
1101-11501101EVASGTQSGG1111TEAEAVPAQK1121ERPPAPSSFV1131FQEETKEQSK1141MEDTLEHTDK
1151-12001151EVSVETVSIL1161SKTEGTQEAD1171QYADEKTKDV1181PFFEGLEGSI1191DTGITVSREK
1201-12501201VTEVALKGEG1211TEEAECKKDD1221ALELQSHAKS1231PPSPVEREMV1241VQVEREKTEA
1251-13001251EPTHVNEEKL1261EHETAVTVSE1271EVSKQLLQTV1281NVPIIDGAKE1291VSSLEGSPPP
1301-13501301CLGQEEAVCT1311KIQVQSSEAS1321FTLTAAAEEE1331KVLGETANIL1341ETGETLEPAG
1351-14001351AHLVLEEKSS1361EKNEDFAAHP1371GEDAVPTGPD1381CQAKSTPVIV1391SATTKKGLSS
1401-14501401DLEGEKTTSL1411KWKSDEVDEQ1421VACQEVKVSV1431AIEDLEPENG1441ILELETKSSK
1451-15001451LVQNIIQTAV1461DQFVRTEETA1471TEMLTSELQT1481QAHVIKADSQ1491DAGQETEKEG
1501-15501501EEPQASAQDE1511TPITSAKEES1521ESTAVGQAHS1531DISKDMSEAS1541EKTMTVEVEG
1551-16001551STVNDQQLEE1561VVLPSEEEGG1571GAGTKSVPED1581DGHALLAERI1591EKSLVEPKED
1601-16501601EKGDDVDDPE1611NQNSALADTD1621ASGGLTKESP1631DTNGPKQKEK1641EDAQEVELQE
1651-16841651GKVHSESDKA1661ITPQAQEELQ1671KQERESAKSE1681LTES
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 265 | - | - | - |
Deep-Palm: 0.95
|
|
| 470 | - | - | - |
Deep-Palm: 0.98
|
|
| 578 | - | - | - |
Deep-Palm: 0.96
|
|
| 684 | - | - | - |
Deep-Palm: 0.95
|
|
| 1139 | - | - | - |
Deep-Palm: 0.90
|
|
| 1314 | - | - | - |
Deep-Palm: 0.97
|
|
| 1399 | - | - | - |
Deep-Palm: 0.94
|
|
| 1407 | - | - | - |
Deep-Palm: 0.92
|
|
| 1479 | - | - | - |
Deep-Palm: 0.85
|
|
| 1521 | - | - | - |
Deep-Palm: 0.90
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
PC3
Specificity: 0.444
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.444
4/4 (100.0%)
1
HeLa cell
Specificity: 0.111
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 308 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 578 | C → Y | 0.001764 | SNP | Missense Mutation | LUAD |
| 622 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 671 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 1106 | F → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1184 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |