Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q02952-3 | AKAP12 | A-kinase anchor protein 12 (AKAP-12) … | Homo sapiens (Human) | 1677 aa |
Protein Details: Q02952-3 (AKAP12)
Protein Information
| Accession | Q02952-3 |
|---|---|
| Protein Names | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) |
| Gene Symbol | AKAP12 |
| Organism | Homo sapiens (Human) |
| Length | 1677 aa |
| Isoforms | |
| Related PMIDs | 29575903 32944167 36430497 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MVGQRDSEDV11SKRDSDKEMA21TKSAVVHDIT31DDGQEETPEI41IEQIPSSESN
51-10051LEELTQPTES61QANDIGFKKV71FKFVGFKFTV81KKDKTEKPDT91VQLLTVKKDE
101-150101GEGAAGAGDH111KDPSLGAGEA121ASKESEPKQS131TEKPEETLKR141EQSHAEISPP
151-200151AESGQAVEEC161KEEGEEKQEK171EPSKSAESPT181SPVTSETGST191FKKFFTQGWA
201-250201GWRKKTSFRK211PKEDEVEASE221KKKEQEPEKV231DTEEDGKAEV241ASEKLTASEQ
251-300251AHPQEPAESA261HEPRLSAEYE271KVELPSEEQV281SGSQGPSEEK291PAPLATEVFD
301-350301EKIEVHQEEV311VAEVHVSTVE321ERTEEQKTEV331EETAGSVPAE341ELVEMDAEPQ
351-400351EAEPAKELVK361LKETCVSGED371PTQGADLSPD381EKVLSKPPEG391VVSEVEMLSS
401-450401QERMKVQGSP411LKKLFTSTGL421KKLSGKKQKG431KRGGGDEESG441EHTQVPADSP
451-500451DSQEEQKGES461SASSPEEPEE471ITCLEKGLAE481VQQDGEAEEG491ATSDGEKKRE
501-550501GVTPWASFKK511MVTPKKRVRR521PSESDKEDEL531DKVKSATLSS541TESTASEMQE
551-600551EMKGSVEEPK561PEEPKRKVDT571SVSWEALICV581GSSKKRARRG591SSSDEEGGPK
601-650601AMGGDHQKAD611EAGKDKETGT621DGILAGSQEH631DPGQGSSSPE641QAGSPTEGEG
651-700651VSTWESFKRL661VTPRKKSKSK671LEEKSEDSIA681GSGVEHSTPD691TEPGKEESWV
701-750701SIKKFIPGRR711KKRPDGKQEQ721APVEDAGPTG731ANEDDSDVPA741VVPLSEYDAV
751-800751EREKMEAQQA761QKSAEQPEQK771AATEVSKELS781ESQVHMMAAA791VADGTRAATI
801-850801IEERSPSWIS811ASVTEPLEQV821EAEAALLTEE831VLEREVIAEE841EPPTVTEPLP
851-900851ENREARGDTV861VSEAELTPEA871VTAAETAGPL881GAEEGTEASA891AEETTEMVSA
901-950901VSQLTDSPDT911TEEATPVQEV921EGGVPDIEEQ931ERRTQEVLQA941VAEKVKEESQ
951-1000951LPGTGGPEDV961LQPVQRAEAE971RPEEQAEASG981LKKETDVVLK991VDAQEAKTEP
1001-10501001FTQGKVVGQT1011TPESFEKAPQ1021VTESIESSEL1031VTTCQAETLA1041GVKSQEMVME
1051-11001051QAIPPDSVET1061PTDSETDGST1071PVADFDAPGT1081TQKDEIVEIH1091EENEVASGTQ
1101-11501101SGGTEAEAVP1111AQKERPPAPS1121SFVFQEETKE1131QSKMEDTLEH1141TDKEVSVETV
1151-12001151SILSKTEGTQ1161EADQYADEKT1171KDVPFFEGLE1181GSIDTGITVS1191REKVTEVALK
1201-12501201GEGTEEAECK1211KDDALELQSH1221AKSPPSPVER1231EMVVQVEREK1241TEAEPTHVNE
1251-13001251EKLEHETAVT1261VSEEVSKQLL1271QTVNVPIIDG1281AKEVSSLEGS1291PPPCLGQEEA
1301-13501301VCTKIQVQSS1311EASFTLTAAA1321EEEKVLGETA1331NILETGETLE1341PAGAHLVLEE
1351-14001351KSSEKNEDFA1361AHPGEDAVPT1371GPDCQAKSTP1381VIVSATTKKG1391LSSDLEGEKT
1401-14501401TSLKWKSDEV1411DEQVACQEVK1421VSVAIEDLEP1431ENGILELETK1441SSKLVQNIIQ
1451-15001451TAVDQFVRTE1461ETATEMLTSE1471LQTQAHVIKA1481DSQDAGQETE1491KEGEEPQASA
1501-15501501QDETPITSAK1511EESESTAVGQ1521AHSDISKDMS1531EASEKTMTVE1541VEGSTVNDQQ
1551-16001551LEEVVLPSEE1561EGGGAGTKSV1571PEDDGHALLA1581ERIEKSLVEP1591KEDEKGDDVD
1601-16501601DPENQNSALA1611DTDASGGLTK1621ESPDTNGPKQ1631KEKEDAQEVE1641LQEGKVHSES
1651-16771651DKAITPQAQE1661ELQKQERESA1671KSELTES
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 265 | - | - | - |
Deep-Palm: 0.95
|
|
| 470 | - | - | - |
Deep-Palm: 0.98
|
|
| 578 | - | - | - |
Deep-Palm: 0.96
|
|
| 684 | - | - | - |
Deep-Palm: 0.95
|
|
| 1139 | - | - | - |
Deep-Palm: 0.90
|
|
| 1314 | - | - | - |
Deep-Palm: 0.97
|
|
| 1399 | - | - | - |
Deep-Palm: 0.94
|
|
| 1407 | - | - | - |
Deep-Palm: 0.92
|
|
| 1479 | - | - | - |
Deep-Palm: 0.85
|
|
| 1521 | - | - | - |
Deep-Palm: 0.90
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
PC3
Specificity: 0.444
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.444
4/4 (100.0%)
1
HeLa cell
Specificity: 0.111
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 308 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 578 | C → Y | 0.001764 | SNP | Missense Mutation | LUAD |
| 622 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 671 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 1106 | F → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1184 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |