Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q03518 | TAP1 | Antigen peptide transporter 1 (APT1) … | Homo sapiens (Human) | 748 aa |
Protein Details: Q03518 (TAP1)
Protein Information
| Accession | Q03518 |
|---|---|
| Protein Names | Antigen peptide transporter 1 (APT1) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 2) (Peptide supply factor 1) (Peptide transporter PSF1) (PSF-1) (Peptide transporter TAP1) (Peptide transporter involved in antigen processing 1) (Really interesting new gene 4 protein) (RING4) |
| Gene Symbol | TAP1 |
| Organism | Homo sapiens (Human) |
| Length | 748 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 31251020 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MASSRCPAPR11GCRCLPGASL21AWLGTVLLLL31ADWVLLRTAL41PRIFSLLVPT
51-10051ALPLLRVWAV61GLSRWAVLWL71GACGVLRATV81GSKSENAGAQ91GWLAALKPLA
101-150101AALGLALPGL111ALFRELISWG121APGSADSTRL131LHWGSHPTAF141VVSYAAALPA
151-200151AALWHKLGSL161WVPGGQGGSG171NPVRRLLGCL181GSETRRLSLF191LVLVVLSSLG
201-250201EMAIPFFTGR211LTDWILQDGS221ADTFTRNLTL231MSILTIASAV241LEFVGDGIYN
251-300251NTMGHVHSHL261QGEVFGAVLR271QETEFFQQNQ281TGNIMSRVTE291DTSTLSDSLS
301-350301ENLSLFLWYL311VRGLCLLGIM321LWGSVSLTMV331TLITLPLLFL341LPKKVGKWYQ
351-400351LLEVQVRESL361AKSSQVAIEA371LSAMPTVRSF381ANEEGEAQKF391REKLQEIKTL
401-450401NQKEAVAYAV411NSWTTSISGM421LLKVGILYIG431GQLVTSGAVS441SGNLVTFVLY
451-500451QMQFTQAVEV461LLSIYPRVQK471AVGSSEKIFE481YLDRTPRCPP491SGLLTPLHLE
501-550501GLVQFQDVSF511AYPNRPDVLV521LQGLTFTLRP531GEVTALVGPN541GSGKSTVAAL
551-600551LQNLYQPTGG561QLLLDGKPLP571QYEHRYLHRQ581VAAVGQEPQV591FGRSLQENIA
601-650601YGLTQKPTME611EITAAAVKSG621AHSFISGLPQ631GYDTEVDEAG641SQLSGGQRQA
651-700651VALARALIRK661PCVLILDDAT671SALDANSQLQ681VEQLLYESPE691RYSRSVLLIT
701-748701QHLSLVEQAD711HILFLEGGAI721REGGTHQQLM731EKKGCYWAMV741QAPADAPE
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 6 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.03
|
|
| 12 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.38
|
|
| 14 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.98
|
|
| 73 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.97
|
|
| 179 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.98
|
|
| 315 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.89
|
|
| 488 | - | - | - |
Deep-Palm: 0.98
|
|
| 662 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.98
|
|
| 735 | - | - | - |
Deep-Palm: 0.79
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
2
LNCaP
Specificity: 0.667
2/2 (100.0%)
1
Jurkat T cell
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 544 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 544 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 547 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 575 | R → C | 0.002294 | SNP | Missense Mutation | OV |
| 589 | R → C | 0.002545 | SNP | Missense Mutation | GBM |