Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q04446 GBE1 1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher … Homo sapiens (Human) 702 aa

Protein Details: Q04446 (GBE1)

Protein Information
AccessionQ04446
Protein Names1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme)
Gene SymbolGBE1
OrganismHomo sapiens (Human)
Length702 aa
IsoformsNo isoforms
Related PMIDs 32944167 33636221
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAPMTPAAR11PEDYEAALNA21ALADVPELAR31LLEIDPYLKP41YAVDFQRRYK
51-10051QFSQILKNIG61ENEGGIDKFS71RGYESFGVHR81CADGGLYCKE91WAPGAEGVFL
101-150101TGDFNGWNPF111SYPYKKLDYG121KWELYIPPKQ131NKSVLVPHGS141KLKVVITSKS
151-200151GEILYRISPW161AKYVVREGDN171VNYDWIHWDP181EHSYEFKHSR191PKKPRSLRIY
201-250201ESHVGISSHE211GKVASYKHFT221CNVLPRIKGL231GYNCIQLMAI241MEHAYYASFG
251-300251YQITSFFAAS261SRYGTPEELQ271ELVDTAHSMG281IIVLLDVVHS291HASKNSADGL
301-350301NMFDGTDSCY311FHSGPRGTHD321LWDSRLFAYS331SWEILRFLLS341NIRWWLEEYR
351-400351FDGFRFDGVT361SMLYHHHGVG371QGFSGDYSEY381FGLQVDEDAL391TYLMLANHLV
401-450401HTLCPDSITI411AEDVSGMPAL421CSPISQGGGG431FDYRLAMAIP441DKWIQLLKEF
451-500451KDEDWNMGDI461VYTLTNRRYL471EKCIAYAESH481DQALVGDKSL491AFWLMDAEMY
501-550501TNMSVLTPFT511PVIDRGIQLH521KMIRLITHGL531GGEGYLNFMG541NEFGHPEWLD
551-600551FPRKGNNESY561HYARRQFHLT571DDDLLRYKFL581NNFDRDMNRL591EERYGWLAAP
601-650601QAYVSEKHEG611NKIIAFERAG621LLFIFNFHPS631KSYTDYRVGT641ALPGKFKIVL
651-700651DSDAAEYGGH661QRLDHSTDFF671SEAFEHNGRP681YSLLVYIPSR691VALILQNVDL
701-702701PN
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
81 - - -
Deep-Palm: 0.69
88 - - -
Deep-Palm: 0.50
221 - - -
GPS-Palm: 0.89
Deep-Palm: 0.90
234 - - -
GPS-Palm: 0.72
Deep-Palm: 0.17
309 - - -
Deep-Palm: 0.11
404 - - -
Deep-Palm: 0.92
421 - - -
GPS-Palm: 0.72
Deep-Palm: 0.88
473 - - -
Deep-Palm: 0.89
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
PC3
Specificity: 0.800
4/4 (100.0%)
1
heart
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
72 G → C 0.003460 SNP Missense Mutation CESC
114 Y → C 0.001764 SNP Missense Mutation LUAD
156 R → C 0.002141 SNP Missense Mutation SKCM
166 R → C 0.002141 SNP Missense Mutation SKCM
202 S → C 0.001014 SNP Missense Mutation BRCA
355 R → C 0.002506 SNP Missense Mutation COAD
355 R → C 0.002141 SNP Missense Mutation SKCM
576 R → C 0.004283 SNP Missense Mutation SKCM
679 R → C 0.002288 SNP Missense Mutation STAD