Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q04828 | AKR1C1 | Aldo-keto reductase family 1 member … | Homo sapiens (Human) | 323 aa |
Protein Details: Q04828 (AKR1C1)
Protein Information
| Accession | Q04828 |
|---|---|
| Protein Names | Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (3beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB) |
| Gene Symbol | AKR1C1 |
| Organism | Homo sapiens (Human) |
| Length | 323 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MDSKYQCVKL11NDGHFMPVLG21FGTYAPAEVP31KSKALEATKL41AIEAGFRHID
51-10051SAHLYNNEEQ61VGLAIRSKIA71DGSVKREDIF81YTSKLWCNSH91RPELVRPALE
101-150101RSLKNLQLDY111VDLYLIHFPV121SVKPGEEVIP131KDENGKILFD141TVDLCATWEA
151-200151VEKCKDAGLA161KSIGVSNFNR171RQLEMILNKP181GLKYKPVCNQ191VECHPYFNQR
201-250201KLLDFCKSKD211IVLVAYSALG221SHREEPWVDP231NSPVLLEDPV241LCALAKKHKR
251-300251TPALIALRYQ261LQRGVVVLAK271SYNEQRIRQN281VQVFEFQLTS291EEMKAIDGLN
301-323301RNVRYLTLDI311FAGPPNYPFS321DEY
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 7 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.02
|
|
| 87 | - | - | - |
Deep-Palm: 0.94
|
|
| 145 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.97
|
|
| 154 | - | - | - |
Deep-Palm: 0.85
|
|
| 188 | - | - | - |
Deep-Palm: 0.46
|
|
| 193 | - | - | - |
Deep-Palm: 0.34
|
|
| 206 | SWISSPALM DBPTM CYSMODDB | Aldo/keto reductase family | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.90
|
| 242 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
frontal cortex
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 55 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 188 | C → G | 0.002294 | SNP | Missense Mutation | OV |
| 188 | C → R | 0.002545 | SNP | Missense Mutation | GBM |
| 216 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 263 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 276 | R → C | 0.002506 | SNP | Missense Mutation | COAD |