Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q04917 | YWHAH | 14-3-3 protein eta (Protein AS1) | Homo sapiens (Human) | 246 aa |
Protein Details: Q04917 (YWHAH)
Protein Information
| Accession | Q04917 |
|---|---|
| Protein Names | 14-3-3 protein eta (Protein AS1) |
| Gene Symbol | YWHAH |
| Organism | Homo sapiens (Human) |
| Length | 246 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGDREQLLQR11ARLAEQAERY21DDMASAMKAV31TELNEPLSNE41DRNLLSVAYK
51-10051NVVGARRSSW61RVISSIEQKT71MADGNEKKLE81KVKAYREKIE91KELETVCNDV
101-150101LSLLDKFLIK111NCNDFQYESK121VFYLKMKGDY131YRYLAEVASG141EKKNSVVEAS
151-200151EAAYKEAFEI161SKEQMQPTHP171IRLGLALNFS181VFYYEIQNAP191EQACLLAKQA
201-246201FDDAIAELDT211LNEDSYKDST221LIMQLLRDNL231TLWTSDQQDE241EAGEGN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 97 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.89
Deep-Palm: 0.96
|
|
| 112 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.90
Deep-Palm: 0.48
|
|
| 194 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.69
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
4
cerebral cortex
Specificity: 0.286
4/4 (100.0%)
3
PC3
Specificity: 0.214
3/3 (100.0%)
1
LNCaP
Specificity: 0.071
1/1 (100.0%)
1
HAP1 cell
Specificity: 0.071
1/1 (100.0%)
1
293T cell
Specificity: 0.071
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.286
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 112 | C → G | 0.001887 | SNP | Missense Mutation | UCEC |
| 112 | C → delins* | 0.001887 | INS | Nonsense Mutation | UCEC |