Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q05329 | GAD2 | Glutamate decarboxylase 2 (EC 4.1.1.15) … | Homo sapiens (Human) | 585 aa |
Protein Details: Q05329 (GAD2)
Protein Information
| Accession | Q05329 |
|---|---|
| Protein Names | Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform) |
| Gene Symbol | GAD2 |
| Organism | Homo sapiens (Human) |
| Length | 585 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | PTMDdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MASPGSGFWS11FGSEDGSGDS21ENPGTARAWC31QVAQKFTGGI41GNKLCALLYG
51-10051DAEKPAESGG61SQPPRAAARK71AACACDQKPC81SCSKVDVNYA91FLHATDLLPA
101-150101CDGERPTLAF111LQDVMNILLQ121YVVKSFDRST131KVIDFHYPNE141LLQEYNWELA
151-200151DQPQNLEEIL161MHCQTTLKYA171IKTGHPRYFN181QLSTGLDMVG191LAADWLTSTA
201-250201NTNMFTYEIA211PVFVLLEYVT221LKKMREIIGW231PGGSGDGIFS241PGGAISNMYA
251-300251MMIARFKMFP261EVKEKGMAAL271PRLIAFTSEH281SHFSLKKGAA291ALGIGTDSVI
301-350301LIKCDERGKM311IPSDLERRIL321EAKQKGFVPF331LVSATAGTTV341YGAFDPLLAV
351-400351ADICKKYKIW361MHVDAAWGGG371LLMSRKHKWK381LSGVERANSV391TWNPHKMMGV
401-450401PLQCSALLVR411EEGLMQNCNQ421MHASYLFQQD431KHYDLSYDTG441DKALQCGRHV
451-500451DVFKLWLMWR461AKGTTGFEAH471VDKCLELAEY481LYNIIKNREG491YEMVFDGKPQ
501-550501HTNVCFWYIP511PSLRTLEDNE521ERMSRLSKVA531PVIKARMMEY541GTTMVSYQPL
551-585551GDKVNFFRMV561ISNPAATHQD571IDFLIEEIER581LGQDL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 30 | DBPTM | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.70
Deep-Palm: 0.83
|
| 45 | DBPTM | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.90
Deep-Palm: 0.96
|
| 73 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.72
|
|
| 75 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.77
|
|
| 80 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.26
|
|
| 82 | - | - | - |
Deep-Palm: 0.27
|
|
| 101 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.87
|
|
| 163 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.44
|
|
| 304 | - | - | - |
Deep-Palm: 0.96
|
|
| 354 | - | - | - |
Deep-Palm: 0.63
|
|
| 404 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.66
|
|
| 418 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.21
|
|
| 446 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.52
|
|
| 474 | - | - | - |
Deep-Palm: 0.82
|
|
| 505 | - | - | - |
Deep-Palm: 0.18
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 1.000
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 45 | C → F | 0.002033 | SNP | Missense Mutation | LUSC |
| 230 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 304 | C → F | 0.001014 | SNP | Missense Mutation | BRCA |
| 304 | C → Y | 0.001014 | SNP | Missense Mutation | BRCA |
| 354 | C → R | 0.001887 | SNP | Missense Mutation | UCEC |
| 404 | C → C | 0.003460 | SNP | Silent | CESC |
| 446 | C → C | 0.002288 | SNP | Silent | STAD |
| 446 | C → Y | 0.002506 | SNP | Missense Mutation | COAD |
| 446 | C → C | 0.001887 | SNP | Silent | UCEC |
| 482 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 505 | C → C | 0.004219 | SNP | Silent | SARC |
| 558 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 580 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |