Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q05329 GAD2; GAD65 Glutamate decarboxylase 2 (EC 4.1.1.15) … Homo sapiens (Human) 585 aa

Protein Details: Q05329 (GAD2)

Protein Information
Accession Q05329
Protein Names Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform)
Gene Symbol GAD2; GAD65
Organism Homo sapiens (Human)
Length 585 aa
Isoforms No isoforms
Related PMIDs 36430497
Database Sources dbPTM
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
2
Cerebral cortex
Specificity: 1.000
2/4 (50.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MASPGSGFWS11FGSEDGSGDS21ENPGTARAWC31QVAQKFTGGI41GNKLCALLYG
51-10051DAEKPAESGG61SQPPRAAARK71AACACDQKPC81SCSKVDVNYA91FLHATDLLPA
101-150101CDGERPTLAF111LQDVMNILLQ121YVVKSFDRST131KVIDFHYPNE141LLQEYNWELA
151-200151DQPQNLEEIL161MHCQTTLKYA171IKTGHPRYFN181QLSTGLDMVG191LAADWLTSTA
201-250201NTNMFTYEIA211PVFVLLEYVT221LKKMREIIGW231PGGSGDGIFS241PGGAISNMYA
251-300251MMIARFKMFP261EVKEKGMAAL271PRLIAFTSEH281SHFSLKKGAA291ALGIGTDSVI
301-350301LIKCDERGKM311IPSDLERRIL321EAKQKGFVPF331LVSATAGTTV341YGAFDPLLAV
351-400351ADICKKYKIW361MHVDAAWGGG371LLMSRKHKWK381LSGVERANSV391TWNPHKMMGV
401-450401PLQCSALLVR411EEGLMQNCNQ421MHASYLFQQD431KHYDLSYDTG441DKALQCGRHV
451-500451DVFKLWLMWR461AKGTTGFEAH471VDKCLELAEY481LYNIIKNREG491YEMVFDGKPQ
501-550501HTNVCFWYIP511PSLRTLEDNE521ERMSRLSKVA531PVIKARMMEY541GTTMVSYQPL
551-585551GDKVNFFRMV561ISNPAATHQD571IDFLIEEIER581LGQDL
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
30 DBPTM Prediction (Low) - -
45 DBPTM Prediction (High) - -
73 Prediction (High) - -
75 Prediction (High) - -
80 Prediction (Low) - -
101 Prediction (Low) - -
163 Prediction (Medium) - -
404 Prediction (Medium) - -
418 Prediction (Low) - -
446 Prediction (Low) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
45 C → F 0.002033 SNP Missense Mutation LUSC
230 W → C 0.001764 SNP Missense Mutation LUAD
304 C → F 0.001014 SNP Missense Mutation BRCA
304 C → Y 0.001014 SNP Missense Mutation BRCA
354 C → R 0.001887 SNP Missense Mutation UCEC
404 C → C 0.003460 SNP Silent CESC
446 C → C 0.002288 SNP Silent STAD
446 C → Y 0.002506 SNP Missense Mutation COAD
446 C → C 0.001887 SNP Silent UCEC
482 Y → C 0.001887 SNP Missense Mutation UCEC
505 C → C 0.004219 SNP Silent SARC
558 R → C 0.002020 SNP Missense Mutation PRAD
580 R → C 0.001014 SNP Missense Mutation BRCA