Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q06830 | PRDX1 | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer … | Homo sapiens (Human) | 199 aa |
Protein Details: Q06830 (PRDX1)
Protein Information
| Accession | Q06830 |
|---|---|
| Protein Names | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) |
| Gene Symbol | PRDX1 |
| Organism | Homo sapiens (Human) |
| Length | 199 aa |
| Isoforms | No isoforms |
| Related PMIDs | 25914232 29733200 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSSGNAKIGH11PAPNFKATAV21MPDGQFKDIS31LSDYKGKYVV41FFFYPLDFTF
51-10051VCPTEIIAFS61DRAEEFKKLN71CQVIGASVDS81HFCHLAWVNT91PKKQGGLGPM
101-150101NIPLVSDPKR111TIAQDYGVLK121ADEGISFRGL131FIIDDKGILR141QITVNDLPVG
151-199151RSVDETLRLV161QAFQFTDKHG171EVCPAGWKPG181SDTIKPDVQK191SKEYFSKQK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 52 | - | - | - |
Deep-Palm: 0.50
|
|
| 71 | SWISSPALM DBPTM CYSMODDB | AhpC/TSA family | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.85
Deep-Palm: 0.93
|
| 83 | SWISSPALM DBPTM CYSMODDB | AhpC/TSA family | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.57
|
| 173 | SWISSPALM DBPTM CYSMODDB | C-terminal domain of 1-Cys peroxiredoxin |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
Deep-Palm: 0.70
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.235
4
PC3
Specificity: 0.190
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.190
4/4 (100.0%)
3
LNCaP
Specificity: 0.143
3/3 (100.0%)
3
CEM 174 cell
Specificity: 0.143
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.095
2/2 (100.0%)
1
293T cell
Specificity: 0.048
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.190
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 71 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |