Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q07065 | CKAP4 | Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking … | Homo sapiens (Human) | 602 aa |
Protein Details: Q07065 (CKAP4)
Protein Information
| Accession | Q07065 |
|---|---|
| Protein Names | Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63) |
| Gene Symbol | CKAP4 |
| Organism | Homo sapiens (Human) |
| Length | 602 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 22496122 24357059 26111759 29575903 29733200 31251020 32651440 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPSAKQRGSK11GGHGAASPSE21KGAHPSGGAD31DVAKKPPPAP41QQPPPPPAPH
51-10051PQQHPQQHPQ61NQAHGKGGHR71GGGGGGGKSS81SSSSASAAAA91AAAASSSASC
101-150101SRRLGRALNF111LFYLALVAAA121AFSGWCVHHV131LEEVQQVRRS141HQDFSRQREE
151-200151LGQGLQGVEQ161KVQSLQATFG171TFESILRSSQ181HKQDLTEKAV191KQGESEVSRI
201-250201SEVLQKLQNE211ILKDLSDGIH221VVKDARERDF231TSLENTVEER241LTELTKSIND
251-300251NIAIFTEVQK261RSQKEINDMK271AKVASLEESE281GNKQDLKALK291EAVKEIQTSA
301-350301KSREWDMEAL311RSTLQTMESD321IYTEVRELVS331LKQEQQAFKE341AADTERLALQ
351-400351ALTEKLLRSE361ESVSRLPEEI371RRLEEELRQL381KSDSHGPKED391GGFRHSEAFE
401-450401ALQQKSQGLD411SRLQHVEDGV421LSMQVASARQ431TESLESLLSK441SQEHEQRLAA
451-500451LQGRLEGLGS461SEADQDGLAS471TVRSLGETQL481VLYGDVEELK491RSVGELPSTV
501-550501ESLQKVQEQV511HTLLSQDQAQ521AARLPPQDFL531DRLSSLDNLK541ASVSQVEADL
551-600551KMLRTAVDSL561VAYSVKIETN571ENNLESAKGL581LDDLRNDLDR591LFVKVEKIHE
601-602601KV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 100 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.94
Deep-Palm: 0.98
|
| 126 | - | - | - |
Deep-Palm: 0.48
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.200
5
Jurkat T cell
Specificity: 0.167
5/5 (100.0%)
4
LNCaP
Specificity: 0.133
4/4 (100.0%)
4
Primary T cell
Specificity: 0.133
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.133
4/4 (100.0%)
2
HAP1 cell
Specificity: 0.067
2/2 (100.0%)
2
HeLa cell
Specificity: 0.067
2/2 (100.0%)
1
EC cell
Specificity: 0.033
1/1 (100.0%)
1
293T cell
Specificity: 0.033
1/1 (100.0%)
1
HUVECs
Specificity: 0.033
1/1 (100.0%)
1
DU145 cell
Specificity: 0.033
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
Cerebral Cortex (Mass)
Specificity: 0.100
3/4 (75.0%)
2
LNCaP cells (Mass)
Specificity: 0.067
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 326 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 429 | R → C | 0.006993 | SNP | Missense Mutation | LAML |
| 454 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 494 | G → C | 0.002545 | SNP | Missense Mutation | GBM |