Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q08043 | ACTN3 | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform … | Homo sapiens (Human) | 901 aa |
Protein Details: Q08043 (ACTN3)
Protein Information
| Accession | Q08043 |
|---|---|
| Protein Names | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) |
| Gene Symbol | ACTN3 |
| Organism | Homo sapiens (Human) |
| Length | 901 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MMMVMQPEGL11GAGEGRFAGG21GGGGEYMEQE31EDWDRDLLLD41PAWEKQQRKT
51-10051FTAWCNSHLR61KAGTQIENIE71EDFRNGLKLM81LLLEVISGER91LPRPDKGKMR
101-150101FHKIANVNKA111LDFIASKGVK121LVSIGAEEIV131DGNLKMTLGM141IWTIILRFAI
151-200151QDISVEETSA161KEGLLLWCQR171KTAPYRNVNV181QNFHTSWKDG191LALCALIHRH
201-250201RPDLIDYAKL211RKDDPIGNLN221TAFEVAEKYL231DIPKMLDAED241IVNTPKPDEK
251-300251AIMTYVSCFY261HAFAGAEQAE271TAANRICKVL281AVNQENEKLM291EEYEKLASEL
301-350301LEWIRRTVPW311LENRVGEPSM321SAMQRKLEDF331RDYRRLHKPP341RIQEKCQLEI
351-400351NFNTLQTKLR361LSHRPAFMPS371EGKLVSDIAN381AWRGLEQVEK391GYEDWLLSEI
401-450401RRLQRLQHLA411EKFRQKASLH421EAWTRGKEEM431LSQRDYDSAL441LQEVRALLRR
451-500451HEAFESDLAA461HQDRVEHIAA471LAQELNELDY481HEAASVNSRC491QAICDQWDNL
501-550501GTLTQKRRDA511LERMEKLLET521IDRLQLEFAR531RAAPFNNWLD541GAVEDLQDVW
551-600551LVHSVEETQS561LLTAHDQFKA571TLPEADRERG581AIMGIQGEIQ591KICQTYGLRP
601-650601CSTNPYITLS611PQDINTKWDM621VRKLVPSCDQ631TLQEELARQQ641VNERLRRQFA
651-700651AQANAIGPWI661QAKVEEVGRL671AAGLAGSLEE681QMAGLRQQEQ691NIINYKTNID
701-750701RLEGDHQLLQ711ESLVFDNKHT721VYSMEHIRVG731WEQLLTSIAR741TINEVENQVL
751-800751TRDAKGLSQE761QLNEFRASFN771HFDRKQNGMM781EPDDFRACLI791SMGYDLGEVE
801-850801FARIMTMVDP811NAAGVVTFQA821FIDFMTRETA831ETDTTEQVVA841SFKILAGDKN
851-900851YITPEELRRE861LPAKQAEYCI871RRMVPYKGSG881APAGALDYVA891FSSALYGESD
901-901901L
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 55 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.72
|
|
| 168 | SWISSPALM DBPTM CYSMODDB | Calponin homology (CH) domain |
HeLa
(29575903)
| - |
GPS-Palm: 0.96
Deep-Palm: 0.96
|
| 194 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.92
|
|
| 258 | - | - | - |
Deep-Palm: 0.73
|
|
| 277 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.96
|
|
| 346 | SWISSPALM DBPTM CYSMODDB | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.87
|
| 490 | - | - | - |
Deep-Palm: 0.23
|
|
| 494 | - | - | - |
Deep-Palm: 0.36
|
|
| 593 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.49
|
|
| 601 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.36
|
|
| 628 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.87
|
|
| 788 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.34
|
|
| 869 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
LNCaP
Specificity: 1.000
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 74 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 100 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 100 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 176 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 325 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 372 | G → C | 0.002294 | SNP | Missense Mutation | OV |
| 402 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 436 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 494 | C → C | 0.008130 | SNP | Silent | THYM |
| 628 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 803 | R → C | 0.002545 | SNP | Missense Mutation | GBM |