Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q08043 | ACTN3 | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform … | Homo sapiens (Human) | 901 aa |
Protein Details: Q08043 (ACTN3)
Protein Information
| Accession | Q08043 |
|---|---|
| Protein Names | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) |
| Gene Symbol | ACTN3 |
| Organism | Homo sapiens (Human) |
| Length | 901 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
34
LNCaP cells
Specificity: 1.000
34/46 (73.9%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MMMVMQPEGL11GAGEGRFAGG21GGGGEYMEQE31EDWDRDLLLD41PAWEKQQRKT
51-10051FTAWCNSHLR61KAGTQIENIE71EDFRNGLKLM81LLLEVISGER91LPRPDKGKMR
101-150101FHKIANVNKA111LDFIASKGVK121LVSIGAEEIV131DGNLKMTLGM141IWTIILRFAI
151-200151QDISVEETSA161KEGLLLWCQR171KTAPYRNVNV181QNFHTSWKDG191LALCALIHRH
201-250201RPDLIDYAKL211RKDDPIGNLN221TAFEVAEKYL231DIPKMLDAED241IVNTPKPDEK
251-300251AIMTYVSCFY261HAFAGAEQAE271TAANRICKVL281AVNQENEKLM291EEYEKLASEL
301-350301LEWIRRTVPW311LENRVGEPSM321SAMQRKLEDF331RDYRRLHKPP341RIQEKCQLEI
351-400351NFNTLQTKLR361LSHRPAFMPS371EGKLVSDIAN381AWRGLEQVEK391GYEDWLLSEI
401-450401RRLQRLQHLA411EKFRQKASLH421EAWTRGKEEM431LSQRDYDSAL441LQEVRALLRR
451-500451HEAFESDLAA461HQDRVEHIAA471LAQELNELDY481HEAASVNSRC491QAICDQWDNL
501-550501GTLTQKRRDA511LERMEKLLET521IDRLQLEFAR531RAAPFNNWLD541GAVEDLQDVW
551-600551LVHSVEETQS561LLTAHDQFKA571TLPEADRERG581AIMGIQGEIQ591KICQTYGLRP
601-650601CSTNPYITLS611PQDINTKWDM621VRKLVPSCDQ631TLQEELARQQ641VNERLRRQFA
651-700651AQANAIGPWI661QAKVEEVGRL671AAGLAGSLEE681QMAGLRQQEQ691NIINYKTNID
701-750701RLEGDHQLLQ711ESLVFDNKHT721VYSMEHIRVG731WEQLLTSIAR741TINEVENQVL
751-800751TRDAKGLSQE761QLNEFRASFN771HFDRKQNGMM781EPDDFRACLI791SMGYDLGEVE
801-850801FARIMTMVDP811NAAGVVTFQA821FIDFMTRETA831ETDTTEQVVA841SFKILAGDKN
851-900851YITPEELRRE861LPAKQAEYCI871RRMVPYKGSG881APAGALDYVA891FSSALYGESD
901-901901L
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 55 | Prediction (Medium) | - | - |
| 168 | CYSMODDB SWISSPALM DBPTM Prediction (High) | Calponin homology (CH) domain | - |
| 194 | Prediction (Medium) | - | - |
| 277 | Prediction (Low) | - | - |
| 346 | CYSMODDB SWISSPALM DBPTM | - | - |
| 593 | Prediction (Medium) | - | - |
| 601 | Prediction (Low) | - | - |
| 628 | Prediction (Medium) | - | - |
| 788 | Prediction (Medium) | - | - |
| 869 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 74 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 100 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 100 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 176 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 325 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 372 | G → C | 0.002294 | SNP | Missense Mutation | OV |
| 402 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 436 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 494 | C → C | 0.008130 | SNP | Silent | THYM |
| 628 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 803 | R → C | 0.002545 | SNP | Missense Mutation | GBM |