Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q09470 KCNA1 Potassium voltage-gated channel subfamily A … Homo sapiens (Human) 495 aa

Protein Details: Q09470 (KCNA1)

Protein Information
AccessionQ09470
Protein NamesPotassium voltage-gated channel subfamily A member 1 (Voltage-gated K(+) channel HuKI) (Voltage-gated potassium channel HBK1) (Voltage-gated potassium channel subunit Kv1.1)
Gene SymbolKCNA1
OrganismHomo sapiens (Human)
Length495 aa
IsoformsNo isoforms
Related PMIDs 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MTVMSGENVD11EASAAPGHPQ21DGSYPRQADH31DDHECCERVV41INISGLRFET
51-10051QLKTLAQFPN61TLLGNPKKRM71RYFDPLRNEY81FFDRNRPSFD91AILYYYQSGG
101-150101RLRRPVNVPL111DMFSEEIKFY121ELGEEAMEKF131REDEGFIKEE141ERPLPEKEYQ
151-200151RQVWLLFEYP161ESSGPARVIA171IVSVMVILIS181IVIFCLETLP191ELKDDKDFTG
201-250201TVHRIDNTTV211IYNSNIFTDP221FFIVETLCII231WFSFELVVRF241FACPSKTDFF
251-300251KNIMNFIDIV261AIIPYFITLG271TEIAEQEGNQ281KGEQATSLAI291LRVIRLVRVF
301-350301RIFKLSRHSK311GLQILGQTLK321ASMRELGLLI331FFLFIGVILF341SSAVYFAEAE
351-400351EAESHFSSIP361DAFWWAVVSM371TTVGYGDMYP381VTIGGKIVGS391LCAIAGVLTI
401-450401ALPVPVIVSN411FNYFYHRETE421GEEQAQLLHV431SSPNLASDSD441LSRRSSSTMS
451-495451KSEYMEIEED461MNNSIAHYRQ471VNIRTANCTT481ANQNCVNKSK491LLTDV
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
35 SKP1/BTB/POZ domain superfamily - -
Deep-Palm: 0.16
36 SKP1/BTB/POZ domain superfamily - -
Deep-Palm: 0.17
185 - - -
GPS-Palm: 0.73
Deep-Palm: 0.86
228 - - -
Deep-Palm: 0.03
243 DBPTM SWISSPALM Ion transport protein - -
GPS-Palm: 0.93
Deep-Palm: 0.07
392 - - -
GPS-Palm: 0.77
Deep-Palm: 0.89
478 - - -
Deep-Palm: 0.27
485 - - -
Deep-Palm: 0.03
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
cerebral cortex
Specificity: 0.500
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.500
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
35 C → C 0.002288 SNP Silent STAD
36 C → Y 0.001887 SNP Missense Mutation UCEC
69 R → C 0.001014 SNP Missense Mutation BRCA
69 R → C 0.002506 SNP Missense Mutation COAD
71 R → C 0.001969 SNP Missense Mutation HNSC
84 R → C 0.002545 SNP Missense Mutation GBM
149 Y → C 0.001887 SNP Missense Mutation UCEC
239 R → C 0.002506 SNP Missense Mutation COAD
256 F → C 0.002141 SNP Missense Mutation SKCM