Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q12805 | EFEMP1 | EGF-containing fibulin-like extracellular matrix protein … | Homo sapiens (Human) | 493 aa |
Protein Details: Q12805 (EFEMP1)
Protein Information
| Accession | Q12805 |
|---|---|
| Protein Names | EGF-containing fibulin-like extracellular matrix protein 1 (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3) |
| Gene Symbol | EFEMP1 |
| Organism | Homo sapiens (Human) |
| Length | 493 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLKALFLTML11TLALVKSQDT21EETITYTQCT31DGYEWDPVRQ41QCKDIDECDI
51-10051VPDACKGGMK61CVNHYGGYLC71LPKTAQIIVN81NEQPQQETQP91AEGTSGATTG
101-150101VVAASSMATS111GVLPGGGFVA121SAAAVAGPEM131QTGRNNFVIR141RNPADPQRIP
151-200151SNPSHRIQCA161AGYEQSEHNV171CQDIDECTAG181THNCRADQVC191INLRGSFACQ
201-250201CPPGYQKRGE211QCVDIDECTI221PPYCHQRCVN231TPGSFYCQCS241PGFQLAANNY
251-300251TCVDINECDA261SNQCAQQCYN271ILGSFICQCN281QGYELSSDRL291NCEDIDECRT
301-350301SSYLCQYQCV311NEPGKFSCMC321PQGYQVVRSR331TCQDINECET341TNECREDEMC
351-400351WNYHGGFRCY361PRNPCQDPYI371LTPENRCVCP381VSNAMCRELP391QSIVYKYMSI
401-450401RSDRSVPSDI411FQIQATTIYA421NTINTFRIKS431GNENGEFYLR441QTSPVSAMLV
451-493451LVKSLSGPRE461HIVDLEMLTV471SSIGTFRTSS481VLRLTIIVGP491FSF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 29 | Laminin | - | - |
Deep-Palm: 0.04
|
|
| 42 | Laminin NOTCH1 EGF-like calcium-binding domain | - | - |
Deep-Palm: 0.02
|
|
| 48 | EGF-like calcium-binding, conserved site Laminin NOTCH1 EGF-like calcium-binding domain EGF/Laminin | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.02
|
|
| 55 | - | - | - |
Deep-Palm: 0.02
|
|
| 61 | - | - | - |
Deep-Palm: 0.06
|
|
| 70 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.17
|
|
| 159 | - | - | - |
Deep-Palm: 0.07
|
|
| 171 | - | - | - |
Deep-Palm: 0.02
|
|
| 177 | - | - | - |
Deep-Palm: 0.02
|
|
| 184 | - | - | - |
Deep-Palm: 0.03
|
|
| 190 | - | - | - |
Deep-Palm: 0.02
|
|
| 199 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.30
|
|
| 201 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.11
|
|
| 212 | - | - | - |
Deep-Palm: 0.01
|
|
| 218 | - | - | - |
Deep-Palm: 0.02
|
|
| 224 | - | - | - |
Deep-Palm: 0.01
|
|
| 228 | - | - | - |
Deep-Palm: 0.01
|
|
| 237 | - | - | - |
Deep-Palm: 0.02
|
|
| 239 | - | - | - |
Deep-Palm: 0.02
|
|
| 252 | - | - | - |
Deep-Palm: 0.02
|
|
| 258 | - | - | - |
Deep-Palm: 0.01
|
|
| 264 | - | - | - |
Deep-Palm: 0.01
|
|
| 268 | - | - | - |
Deep-Palm: 0.01
|
|
| 277 | - | - | - |
Deep-Palm: 0.01
|
|
| 279 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.02
|
|
| 292 | - | - | - |
Deep-Palm: 0.02
|
|
| 298 | - | - | - |
Deep-Palm: 0.02
|
|
| 305 | - | - | - |
Deep-Palm: 0.02
|
|
| 309 | - | - | - |
Deep-Palm: 0.02
|
|
| 318 | - | - | - |
Deep-Palm: 0.02
|
|
| 320 | - | - | - |
Deep-Palm: 0.02
|
|
| 332 | - | - | - |
Deep-Palm: 0.02
|
|
| 338 | - | - | - |
Deep-Palm: 0.02
|
|
| 344 | - | - | - |
Deep-Palm: 0.01
|
|
| 350 | - | - | - |
Deep-Palm: 0.02
|
|
| 359 | - | - | - |
Deep-Palm: 0.03
|
|
| 365 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.03
|
|
| 377 | - | - | - |
Deep-Palm: 0.13
|
|
| 379 | - | - | - |
Deep-Palm: 0.17
|
|
| 386 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.27
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
HUVECs
Specificity: 0.500
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
Cerebral Cortex (Mass)
Specificity: 0.500
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 48 | C → F | 0.002427 | SNP | Missense Mutation | BLCA |
| 148 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 156 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 228 | C → C | 0.001764 | SNP | Silent | LUAD |
| 228 | C → C | 0.002020 | SNP | Silent | PRAD |
| 239 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 343 | E → _C344insVYWGMWSRVG*F | 0.001887 | INS | Nonsense Mutation | UCEC |
| 379 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |