Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q12852 | MAP3K12 | Mitogen-activated protein kinase kinase kinase … | Homo sapiens (Human) | 859 aa |
Protein Details: Q12852 (MAP3K12)
Protein Information
| Accession | Q12852 |
|---|---|
| Protein Names | Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) |
| Gene Symbol | MAP3K12 |
| Organism | Homo sapiens (Human) |
| Length | 859 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MACLHETRTP11SPSFGGFVST21LSEASMRKLD31PDTSDCTPEK41DLTPTHVLQL
51-10051HEQDAGGPGG61AAGSPESRAS71RVRADEVRLQ81CQSGSGFLEG91LFGCLRPVWT
101-150101MIGKAYSTEH111KQQQEDLWEV121PFEEILDLQW131VGSGAQGAVF141LGRFHGEEVA
151-200151VKKVRDLKET161DIKHLRKLKH171PNIITFKGVC181TQAPCYCILM191EFCAQGQLYE
201-250201VLRAGRPVTP211SLLVDWSMGI221AGGMNYLHLH231KIIHRDLKSP241NMLITYDDVV
251-300251KISDFGTSKE261LSDKSTKMSF271AGTVAWMAPE281VIRNEPVSEK291VDIWSFGVVL
301-350301WELLTGEIPY311KDVDSSAIIW321GVGSNSLHLP331VPSSCPDGFK341ILLRQCWNSK
351-400351PRNRPSFRQI361LLHLDIASAD371VLSTPQETYF381KSQAEWREEV391KLHFEKIKSE
401-450401GTCLHRLEEE411LVMRRREELR421HALDIREHYE431RKLERANNLY441MELNALMLQL
451-500451ELKERELLRR461EQALERRCPG471LLKPHPSRGL481LHGNTMEKLI491KKRNVPQKLS
501-550501PHSKRPDILK511TESLLPKLDA521ALSGVGLPGC531PKGPPSPGRS541RRGKTRHRKA
551-600551SAKGSCGDLP561GLRTAVPPHE571PGGPGSPGGL581GGGPSAWEAC591PPALRGLHHD
601-650601LLLRKMSSSS611PDLLSAALGS621RGRGATGGAG631DPGSPPPARG641DTPPSEGSAP
651-700651GSTSPDSPGG661AKGEPPPPVG671PGEGVGLLGT681GREGTSGRGG691SRAGSQHLTP
701-750701AALLYRAAVT711RSQKRGISSE721EEEGEVDSEV731ELTSSQRWPQ741SLNMRQSLST
751-800751FSSENPSDGE761EGTASEPSPS771GTPEVGSTNT781DERPDERSDD791MCSQGSEIPL
801-850801DPPPSEVIPG811PEPSSLPIPH821QELLRERGPP831NSEDSDCDST841ELDNSNSVDA
851-859851LRPPASLPP
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 3 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.02
|
|
| 36 | - | - | - |
Deep-Palm: 0.89
|
|
| 81 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.98
|
|
| 94 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.94
|
|
| 180 | - | - | - |
Deep-Palm: 0.10
|
|
| 185 | - | - | - |
Deep-Palm: 0.03
|
|
| 187 | - | - | - |
Deep-Palm: 0.04
|
|
| 193 | - | - | - |
Deep-Palm: 0.27
|
|
| 335 | - | - | - |
Deep-Palm: 0.22
|
|
| 346 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.16
|
|
| 403 | SWISSPALM | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.97
|
| 468 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.98
|
|
| 530 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.98
|
|
| 556 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.94
|
|
| 590 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.98
|
|
| 792 | - | - | - |
Deep-Palm: 0.57
|
|
| 837 | - | - | - |
Deep-Palm: 0.88
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 94 | C → C | 0.027027 | SNP | Silent | DLBC |
| 143 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 186 | Y → C | 0.006993 | SNP | Missense Mutation | LAML |
| 193 | C → C | 0.001887 | SNP | Silent | UCEC |
| 202 | L → Cfs*23 | 0.001014 | DEL | Frame Shift Del | BRCA |
| 674 | G → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 832 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |