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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q13310 PABPC4 Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding … Homo sapiens (Human) 644 aa

Protein Details: Q13310 (PABPC4)

Protein Information
AccessionQ13310
Protein NamesPolyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)
Gene SymbolPABPC4
OrganismHomo sapiens (Human)
Length644 aa
IsoformsNo isoforms
Related PMIDs 29733200 31382980
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MNAAASSYPM11ASLYVGDLHS21DVTEAMLYEK31FSPAGPVLSI41RVCRDMITRR
51-10051SLGYAYVNFQ61QPADAERALD71TMNFDVIKGK81PIRIMWSQRD91PSLRKSGVGN
101-150101VFIKNLDKSI111DNKALYDTFS121AFGNILSCKV131VCDENGSKGY141AFVHFETQEA
151-200151ADKAIEKMNG161MLLNDRKVFV171GRFKSRKERE181AELGAKAKEF191TNVYIKNFGE
201-250201EVDDESLKEL211FSQFGKTLSV221KVMRDPNGKS231KGFGFVSYEK241HEDANKAVEE
251-300251MNGKEISGKI261IFVGRAQKKV271ERQAELKRKF281EQLKQERISR291YQGVNLYIKN
301-350301LDDTIDDEKL311RKEFSPFGSI321TSAKVMLEDG331RSKGFGFVCF341SSPEEATKAV
351-400351TEMNGRIVGS361KPLYVALAQR371KEERKAHLTN381QYMQRVAGMR391ALPANAILNQ
401-450401FQPAAGGYFV411PAVPQAQGRP421PYYTPNQLAQ431MRPNPRWQQG441GRPQGFQGMP
451-500451SAIRQSGPRP461TLRHLAPTGS471ECPDRLAMDF481GGAGAAQQGL491TDSCQSGGVP
501-550501TAVQNLAPRA511AVAAAAPRAV521APYKYASSVR531SPHPAIQPLQ541APQPAVHVQG
551-600551QEPLTASMLA561AAPPQEQKQM571LGERLFPLIQ581TMHSNLAGKI591TGMLLEIDNS
601-644601ELLHMLESPE611SLRSKVDEAV621AVLQAHHAKK631EAAQKVGAVA641AATS
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
43 RNA BINDING PROTEIN Nucleotide-binding alpha-beta plait domain superfamily RNA-binding domain superfamily RNA recognition motif domain - -
GPS-Palm: 0.89
Deep-Palm: 0.86
128 SWISSPALM DBPTM CYSMODDB RNA recognition motif -
Unknown (32651440)
GPS-Palm: 0.79
Deep-Palm: 0.69
132 - - -
GPS-Palm: 0.69
Deep-Palm: 0.18
339 SWISSPALM DBPTM CYSMODDB RNA recognition motif - -
GPS-Palm: 0.82
Deep-Palm: 0.88
472 - - -
GPS-Palm: 0.66
Deep-Palm: 0.95
494 - - -
Deep-Palm: 0.95
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
HAP1 cell
Specificity: 0.500
1/1 (100.0%)
1
U937 cell
Specificity: 0.500
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
171 G → C 0.002294 SNP Missense Mutation OV
265 R → C 0.002141 SNP Missense Mutation SKCM
436 R → C 0.002288 SNP Missense Mutation STAD
463 R → C 0.002141 SNP Missense Mutation SKCM
509 R → C 0.002427 SNP Missense Mutation BLCA
509 R → C 0.005435 SNP Missense Mutation ESCA
530 R → C 0.002141 SNP Missense Mutation SKCM