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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q13639 HTR4 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) … Homo sapiens (Human) 388 aa

Protein Details: Q13639 (HTR4)

Protein Information
AccessionQ13639
Protein Names5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4)
Gene SymbolHTR4
OrganismHomo sapiens (Human)
Length388 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MDKLDANVSS11EEGFGSVEKV21VLLTFLSTVI31LMAILGNLLV41MVAVCWDRQL
51-10051RKIKTNYFIV61SLAFADLLVS71VLVMPFGAIE81LVQDIWIYGE91VFCLVRTSLD
101-150101VLLTTASIFH111LCCISLDRYY121AICCQPLVYR131NKMTPLRIAL141MLGGCWVIPT
151-200151FISFLPIMQG161WNNIGIIDLI171EKRKFNQNSN181STYCVFMVNK191PYAITCSVVA
201-250201FYIPFLLMVL211AYYRIYVTAK221EHAHQIQMLQ231RAGASSESRP241QSADQHSTHR
251-300251MRTETKAAKT261LCIIMGCFCL271CWAPFFVTNI281VDPFIDYTVP291GQVWTAFLWL
301-350301GYINSGLNPF311LYAFLNKSFR321RAFLIILCCD331DERYRRPSIL341GQTVPCSTTT
351-388351INGSTHVLRD361AVECGGQWES371QCHPPATSPL381VAAQPSDT
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
45 G protein-coupled receptor, rhodopsin-like GPCR, rhodopsin-like, 7TM ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR Family A G protein-coupled receptor-like - -
GPS-Palm: 0.93
Deep-Palm: 0.86
93 - - -
Deep-Palm: 0.91
112 - - -
GPS-Palm: 0.67
Deep-Palm: 0.17
113 - - -
Deep-Palm: 0.17
123 - - -
GPS-Palm: 0.91
Deep-Palm: 0.06
124 - - -
GPS-Palm: 0.91
Deep-Palm: 0.10
145 - - -
GPS-Palm: 0.70
Deep-Palm: 0.74
184 - - -
Deep-Palm: 0.08
196 - - -
Deep-Palm: 0.04
262 - - -
GPS-Palm: 0.76
Deep-Palm: 0.06
267 - - -
GPS-Palm: 0.67
Deep-Palm: 0.03
269 - - -
GPS-Palm: 0.74
Deep-Palm: 0.04
271 - - -
Deep-Palm: 0.02
328 DBPTM SWISSPALM - - -
GPS-Palm: 0.97
Deep-Palm: 0.91
329 DBPTM SWISSPALM - - -
GPS-Palm: 0.96
Deep-Palm: 0.91
346 - - -
Deep-Palm: 0.84
364 - - -
Deep-Palm: 0.22
372 - - -
Deep-Palm: 0.63
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
137 R → C 0.002288 SNP Missense Mutation STAD
137 R → C 0.001887 SNP Missense Mutation UCEC
250 R → C 0.002545 SNP Missense Mutation GBM
250 R → C 0.002033 SNP Missense Mutation LUSC
302 Y → C 0.002506 SNP Missense Mutation COAD
372* C → ? 0.001969 SNP Nonsense Mutation HNSC