Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q14118 | DAG1 | Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein … | Homo sapiens (Human) | 895 aa |
Protein Details: Q14118 (DAG1)
Protein Information
| Accession | Q14118 |
|---|---|
| Protein Names | Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] |
| Gene Symbol | DAG1 |
| Organism | Homo sapiens (Human) |
| Length | 895 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 24357059 29575903 31251020 32944167 33636221 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.806
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
29
LNCaP cells
Specificity: 0.806
29/46 (63.0%)
3
PC3 cells
Specificity: 0.083
3/4 (75.0%)
2
Endothelial cells
Specificity: 0.056
2/2 (100.0%)
1
HeLa cells
Specificity: 0.028
1/1 (100.0%)
1
Liver membrane
Specificity: 0.028
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MRMSVGLSLL11LPLSGRTFLL21LLSVVMAQSH31WPSEPSEAVR41DWENQLEASM
51-10051HSVLSDLHEA61VPTVVGIPDG71TAVVGRSFRV81TIPTDLIASS91GDIIKVSAAG
101-150101KEALPSWLHW111DSQSHTLEGL121PLDTDKGVHY131ISVSATRLGA141NGSHIPQTSS
151-200151VFSIEVYPED161HSELQSVRTA171SPDPGEVVSS181ACAADEPVTV191LTVILDADLT
201-250201KMTPKQRIDL211LHRMRSFSEV221ELHNMKLVPV231VNNRLFDMSA241FMAGPGNAKK
251-300251VVENGALLSW261KLGCSLNQNS271VPDIHGVEAP281AREGAMSAQL291GYPVVGWHIA
301-350301NKKPPLPKRV311RRQIHATPTP321VTAIGPPTTA331IQEPPSRIVP341TPTSPAIAPP
351-400351TETMAPPVRD361PVPGKPTVTI371RTRGAIIQTP381TLGPIQPTRV391SEAGTTVPGQ
401-450401IRPTMTIPGY411VEPTAVATPP421TTTTKKPRVS431TPKPATPSTD441STTTTTRRPT
451-500451KKPRTPRPVP461RVTTKVSITR471LETASPPTRI481RTTTSGVPRG491GEPNQRPELK
501-550501NHIDRVDAWV511GTYFEVKIPS521DTFYDHEDTT531TDKLKLTLKL541REQQLVGEKS
551-600551WVQFNSNSQL561MYGLPDSSHV571GKHEYFMHAT581DKGGLSAVDA591FEIHVHRRPQ
601-650601GDRAPARFKA611KFVGDPALVL621NDIHKKIALV631KKLAFAFGDR641NCSTITLQNI
651-700651TRGSIVVEWT661NNTLPLEPCP671KEQIAGLSRR681IAEDDGKPRP691AFSNALEPDF
701-750701KATSITVTGS711GSCRHLQFIP721VVPPRRVPSE731APPTEVPDRD741PEKSSEDDVY
751-800751LHTVIPAVVV761AAILLIAGII771AMICYRKKRK781GKLTLEDQAT791FIKKGVPIIF
801-850801ADELDDSKPP811PSSSMPLILQ821EEKAPLPPPE831YPNQSVPETT841PLNQDTMGEY
851-895851TPLRDEDPNA861PPYQPPPPFT871APMEGKGSRP881KNMTPYRSPP891PYVPP
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 264 | Prediction (Medium) | - | - |
| 642 | Prediction (Low) | - | - |
| 669 | Prediction (Low) | - | - |
| 774 | Prediction (High) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 76 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 562 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 711 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 796 | V → Cfs*47 | 0.001887 | DEL | Frame Shift Del | UCEC |
| 831 | Y → C | 0.002141 | SNP | Missense Mutation | SKCM |