Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q14126 | DSG2 | Desmoglein-2 (Cadherin family member 5) … | Homo sapiens (Human) | 1118 aa |
Protein Details: Q14126 (DSG2)
Protein Information
| Accession | Q14126 |
|---|---|
| Protein Names | Desmoglein-2 (Cadherin family member 5) (HDGC) |
| Gene Symbol | DSG2 |
| Organism | Homo sapiens (Human) |
| Length | 1118 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 29575903 29733200 31251020 33636221 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MARSPGRAYA11LLLLLICFNV21GSGLHLQVLS31TRNENKLLPK41HPHLVRQKRA
51-10051WITAPVALRE61GEDLSKKNPI71AKIHSDLAEE81RGLKITYKYT91GKGITEPPFG
101-150101IFVFNKDTGE111LNVTSILDRE121ETPFFLLTGY131ALDARGNNVE141KPLELRIKVL
151-200151DINDNEPVFT161QDVFVGSVEE171LSAAHTLVMK181INATDADEPN191TLNSKISYRI
201-250201VSLEPAYPPV211FYLNKDTGEI221YTTSVTLDRE231EHSSYTLTVE241ARDGNGEVTD
251-300251KPVKQAQVQI261RILDVNDNIP271VVENKVLEGM281VEENQVNVEV291TRIKVFDADE
301-350301IGSDNWLANF311TFASGNEGGY321FHIETDAQTN331EGIVTLIKEV341DYEEMKNLDF
351-400351SVIVANKAAF361HKSIRSKYKP371TPIPIKVKVK381NVKEGIHFKS391SVISIYVSES
401-450401MDRSSKGQII411GNFQAFDEDT421GLPAHARYVK431LEDRDNWISV441DSVTSEIKLA
451-500451KLPDFESRYV461QNGTYTVKIV471AISEDYPRKT481ITGTVLINVE491DINDNCPTLI
501-550501EPVQTICHDA511EYVNVTAEDL521DGHPNSGPFS531FSVIDKPPGM541AEKWKIARQE
551-600551STSVLLQQSE561KKLGRSEIQF571LISDNQGFSC581PEKQVLTLTV591CECLHGSGCR
601-650601EAQHDSYVGL611GPAAIALMIL621AFLLLLLVPL631LLLMCHCGKG641AKGFTPIPGT
651-700651IEMLHPWNNE661GAPPEDKVVP671SFLPVDQGGS681LVGRNGVGGM691AKEATMKGSS
701-750701SASIVKGQHE711MSEMDGRWEE721HRSLLSGRAT731QFTGATGAIM741TTETTKTARA
751-800751TGASRDMAGA761QAAAVALNEE771FLRNYFTDKA781ASYTEEDENH791TAKDCLLVYS
801-850801QEETESLNAS811IGCCSFIEGE821LDDRFLDDLG831LKFKTLAEVC841LGQKIDINKE
851-900851IEQRQKPATE861TSMNTASHSL871CEQTMVNSEN881TYSSGSSFPV891PKSLQEANAE
901-950901KVTQEIVTER911SVSSRQAQKV921ATPLPDPMAS931RNVIATETSY941VTGSTMPPTT
951-1000951VILGPSQPQS961LIVTERVYAP971ASTLVDQPYA981NEGTVVVTER991VIQPHGGGSN
1001-10501001PLEGTQHLQD1011VPYVMVRERE1021SFLAPSSGVQ1031PTLAMPNIAV1041GQNVTVTERV
1051-11001051LAPASTLQSS1061YQIPTENSMT1071ARNTTVSGAG1081VPGPLPDFGL1091EESGHSNSTI
1101-11181101TTSSTRVTKH1111STVQHSYS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 17 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.98
|
|
| 496 | - | - | - |
Deep-Palm: 0.06
|
|
| 507 | - | - | - |
Deep-Palm: 0.05
|
|
| 580 | - | - | - |
Deep-Palm: 0.53
|
|
| 591 | - | - | - |
Deep-Palm: 0.65
|
|
| 593 | - | - | - |
Deep-Palm: 0.43
|
|
| 599 | - | - | - |
Deep-Palm: 0.73
|
|
| 635 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.99
|
| 637 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.98
|
| 795 | - | - | - |
Deep-Palm: 0.63
|
|
| 813 | - | - | - |
Deep-Palm: 0.64
|
|
| 814 | - | - | - |
Deep-Palm: 0.77
|
|
| 840 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.98
|
|
| 871 | - | - | - |
Deep-Palm: 0.21
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
4
LNCaP
Specificity: 0.364
4/4 (100.0%)
2
HeLa cell
Specificity: 0.182
2/2 (100.0%)
2
Jurkat T cell
Specificity: 0.182
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.091
1/1 (100.0%)
1
heart
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.091
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 261 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 635 | C → W | 0.002141 | SNP | Missense Mutation | SKCM |
| 635 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 637 | C → C | 0.002294 | SNP | Silent | OV |
| 871 | C → F | 0.008130 | SNP | Missense Mutation | THYM |
| 960 | S → C | 0.001969 | SNP | Missense Mutation | LGG |