Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q14183 | DOC2A | Double C2-like domain-containing protein alpha … | Homo sapiens (Human) | 400 aa |
Protein Details: Q14183 (DOC2A)
Protein Information
| Accession | Q14183 |
|---|---|
| Protein Names | Double C2-like domain-containing protein alpha (Doc2) (Doc2-alpha) |
| Gene Symbol | DOC2A |
| Organism | Homo sapiens (Human) |
| Length | 400 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MRGRRGDRMT11INIQEHMAIN21VCPGPIRPIR31QISDYFPRGP41GPEGGGGGGG
51-10051EAPAHLVPLA61LAPPAALLGA71TTPEDGAEVD81SYDSDDATAL91GTLEFDLLYD
101-150101RASCTLHCSI111LRAKGLKPMD121FNGLADPYVK131LHLLPGACKA141NKLKTKTQRN
151-200151TLNPVWNEDL161TYSGITDDDI171THKVLRIAVC181DEDKLSHNEF191IGEIRVPLRR
201-250201LKPSQKKHFN211ICLERQVPLA221SPSSMSAALR231GISCYLKELE241QAEQGQGLLE
251-300251ERGRILLSLS261YSSRRRGLLV271GILRCAHLAA281MDVNGYSDPY291VKTYLRPDVD
301-350301KKSKHKTCVK311KKTLNPEFNE321EFFYEIELST331LATKTLEVTV341WDYDIGKSND
351-400351FIGGVSLGPG361ARGEARKHWS371DCLQQPDAAL381ERWHTLTSEL391PPAAGALSSA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 22 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.09
|
|
| 104 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.77
|
|
| 108 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.45
|
|
| 138 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.93
|
|
| 180 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.17
|
|
| 212 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.93
|
|
| 234 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.97
|
|
| 275 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.56
|
|
| 308 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.78
|
|
| 372 | - | - | - |
Deep-Palm: 0.91
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
HUVECs
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 108 | C → C | 0.002506 | SNP | Silent | COAD |
| 199 | R → C | 0.004219 | SNP | Missense Mutation | SARC |
| 224 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 274 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 343 | Y → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 369 | W → C | 0.001887 | SNP | Missense Mutation | UCEC |