Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q14191 | WRN | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN … | Homo sapiens (Human) | 1432 aa |
Protein Details: Q14191 (WRN)
Protein Information
| Accession | Q14191 |
|---|---|
| Protein Names | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] |
| Gene Symbol | WRN |
| Organism | Homo sapiens (Human) |
| Length | 1432 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31382980 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSEKKLETTA11QQRKCPEWMN21VQNKRCAVEE31RKACVRKSVF41EDDLPFLEFT
51-10051GSIVYSYDAS61DCSFLSEDIS71MSLSDGDVVG81FDMEWPPLYN91RGKLGKVALI
101-150101QLCVSESKCY111LFHVSSMSVF121PQGLKMLLEN131KAVKKAGVGI141EGDQWKLLRD
151-200151FDIKLKNFVE161LTDVANKKLK171CTETWSLNSL181VKHLLGKQLL191KDKSIRCSNW
201-250201SKFPLTEDQK211LYAATDAYAG221FIIYRNLEIL231DDTVQRFAIN241KEEEILLSDM
251-300251NKQLTSISEE261VMDLAKHLPH271AFSKLENPRR281VSILLKDISE291NLYSLRRMII
301-350301GSTNIETELR311PSNNLNLLSF321EDSTTGGVQQ331KQIREHEVLI341HVEDETWDPT
351-400351LDHLAKHDGE361DVLGNKVERK371EDGFEDGVED381NKLKENMERA391CLMSLDITEH
401-450401ELQILEQQSQ411EEYLSDIAYK421STEHLSPNDN431ENDTSYVIES441DEDLEMEMLK
451-500451HLSPNDNEND461TSYVIESDED471LEMEMLKSLE481NLNSGTVEPT491HSKCLKMERN
501-550501LGLPTKEEEE511DDENEANEGE521EDDDKDFLWP531APNEEQVTCL541KMYFGHSSFK
551-600551PVQWKVIHSV561LEERRDNVAV571MATGYGKSLC581FQYPPVYVGK591IGLVISPLIS
601-650601LMEDQVLQLK611MSNIPACFLG621SAQSENVLTD631IKLGKYRIVY641VTPEYCSGNM
651-700651GLLQQLEADI661GITLIAVDEA671HCISEWGHDF681RDSFRKLGSL691KTALPMVPIV
701-750701ALTATASSSI711REDIVRCLNL721RNPQITCTGF731DRPNLYLEVR741RKTGNILQDL
751-800751QPFLVKTSSH761WEFEGPTIIY771CPSRKMTQQV781TGELRKLNLS791CGTYHAGMSF
801-850801STRKDIHHRF811VRDEIQCVIA821TIAFGMGINK831ADIRQVIHYG841APKDMESYYQ
851-900851EIGRAGRDGL861QSSCHVLWAP871ADINLNRHLL881TEIRNEKFRL891YKLKMMAKME
901-950901KYLHSSRCRR911QIILSHFEDK921QVQKASLGIM931GTEKCCDNCR941SRLDHCYSMD
951-1000951DSEDTSWDFG961PQAFKLLSAV971DILGEKFGIG981LPILFLRGSN991SQRLADQYRR
1001-10501001HSLFGTGKDQ1011TESWWKAFSR1021QLITEGFLVE1031VSRYNKFMKI1041CALTKKGRNW
1051-11001051LHKANTESQS1061LILQANEELC1071PKKLLLPSSK1081TVSSGTKEHC1091YNQVPVELST
1101-11501101EKKSNLEKLY1111SYKPCDKISS1121GSNISKKSIM1131VQSPEKAYSS1141SQPVISAQEQ
1151-12001151ETQIVLYGKL1161VEARQKHANK1171MDVPPAILAT1181NKILVDMAKM1191RPTTVENVKR
1201-12501201IDGVSEGKAA1211MLAPLLEVIK1221HFCQTNSVQT1231DLFSSTKPQE1241EQKTSLVAKN
1251-13001251KICTLSQSMA1261ITYSLFQEKK1271MPLKSIAESR1281ILPLMTIGMH1291LSQAVKAGCP
1301-13501301LDLERAGLTP1311EVQKIIADVI1321RNPPVNSDMS1331KISLIRMLVP1341ENIDTYLIHM
1351-14001351AIEILKHGPD1361SGLQPSCDVN1371KRRCFPGSEE1381ICSSSKRSKE1391EVGINTETSS
1401-14321401AERKRRLPVW1411FAKGSDTSKK1421LMDKTKRGGL1431FS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 15 | - | - | - |
Deep-Palm: 0.30
|
|
| 26 | - | - | - |
Deep-Palm: 0.34
|
|
| 34 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.84
|
|
| 62 | - | - | - |
Deep-Palm: 0.35
|
|
| 103 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.51
|
|
| 109 | - | - | - |
Deep-Palm: 0.83
|
|
| 171 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.85
|
|
| 197 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.93
|
|
| 391 | - | - | - |
Deep-Palm: 0.69
|
|
| 494 | - | - | - |
Deep-Palm: 0.92
|
|
| 539 | - | - | - |
Deep-Palm: 0.21
|
|
| 580 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.80
|
|
| 617 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.74
|
|
| 646 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.82
|
|
| 672 | - | - | - |
Deep-Palm: 0.28
|
|
| 717 | - | - | - |
Deep-Palm: 0.65
|
|
| 727 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.83
|
|
| 771 | - | - | - |
Deep-Palm: 0.26
|
|
| 791 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.95
|
|
| 817 | - |
HeLa
(37611173)
| - |
Deep-Palm: 0.27
|
|
| 864 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.57
|
|
| 908 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.61
|
|
| 935 | - | - | - |
Deep-Palm: 0.10
|
|
| 936 | - | - | - |
Deep-Palm: 0.05
|
|
| 939 | - | - | - |
Deep-Palm: 0.03
|
|
| 946 | - | - | - |
Deep-Palm: 0.02
|
|
| 1041 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.84
|
|
| 1070 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.97
|
|
| 1090 | - | - | - |
Deep-Palm: 0.58
|
|
| 1115 | - | - | - |
Deep-Palm: 0.89
|
|
| 1223 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.79
|
|
| 1253 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.80
|
|
| 1299 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.88
Deep-Palm: 0.98
|
|
| 1367 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.73
|
|
| 1374 | - | - | - |
Deep-Palm: 0.53
|
|
| 1382 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.66
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
U937 cell
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 196 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 436 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 596 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 946 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 1041 | C → C | 0.001014 | SNP | Silent | BRCA |
| 1264 | S → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 1374 | C → F | 0.001887 | SNP | Missense Mutation | UCEC |
| 1429 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |