Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q14191 WRN; RECQ3; RECQL2 Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN … Homo sapiens (Human) 1432 aa

Protein Details: Q14191 (WRN)

Protein Information
Accession Q14191
Protein Names Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]
Gene Symbol WRN; RECQ3; RECQL2
Organism Homo sapiens (Human)
Length 1432 aa
Isoforms No isoforms
Related PMIDs 31251020 31382980 37611173
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.857
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
6
LNCaP cells
Specificity: 0.857
6/46 (13.0%)
1
U937 cells
Specificity: 0.143
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MSEKKLETTA11QQRKCPEWMN21VQNKRCAVEE31RKACVRKSVF41EDDLPFLEFT
51-10051GSIVYSYDAS61DCSFLSEDIS71MSLSDGDVVG81FDMEWPPLYN91RGKLGKVALI
101-150101QLCVSESKCY111LFHVSSMSVF121PQGLKMLLEN131KAVKKAGVGI141EGDQWKLLRD
151-200151FDIKLKNFVE161LTDVANKKLK171CTETWSLNSL181VKHLLGKQLL191KDKSIRCSNW
201-250201SKFPLTEDQK211LYAATDAYAG221FIIYRNLEIL231DDTVQRFAIN241KEEEILLSDM
251-300251NKQLTSISEE261VMDLAKHLPH271AFSKLENPRR281VSILLKDISE291NLYSLRRMII
301-350301GSTNIETELR311PSNNLNLLSF321EDSTTGGVQQ331KQIREHEVLI341HVEDETWDPT
351-400351LDHLAKHDGE361DVLGNKVERK371EDGFEDGVED381NKLKENMERA391CLMSLDITEH
401-450401ELQILEQQSQ411EEYLSDIAYK421STEHLSPNDN431ENDTSYVIES441DEDLEMEMLK
451-500451HLSPNDNEND461TSYVIESDED471LEMEMLKSLE481NLNSGTVEPT491HSKCLKMERN
501-550501LGLPTKEEEE511DDENEANEGE521EDDDKDFLWP531APNEEQVTCL541KMYFGHSSFK
551-600551PVQWKVIHSV561LEERRDNVAV571MATGYGKSLC581FQYPPVYVGK591IGLVISPLIS
601-650601LMEDQVLQLK611MSNIPACFLG621SAQSENVLTD631IKLGKYRIVY641VTPEYCSGNM
651-700651GLLQQLEADI661GITLIAVDEA671HCISEWGHDF681RDSFRKLGSL691KTALPMVPIV
701-750701ALTATASSSI711REDIVRCLNL721RNPQITCTGF731DRPNLYLEVR741RKTGNILQDL
751-800751QPFLVKTSSH761WEFEGPTIIY771CPSRKMTQQV781TGELRKLNLS791CGTYHAGMSF
801-850801STRKDIHHRF811VRDEIQCVIA821TIAFGMGINK831ADIRQVIHYG841APKDMESYYQ
851-900851EIGRAGRDGL861QSSCHVLWAP871ADINLNRHLL881TEIRNEKFRL891YKLKMMAKME
901-950901KYLHSSRCRR911QIILSHFEDK921QVQKASLGIM931GTEKCCDNCR941SRLDHCYSMD
951-1000951DSEDTSWDFG961PQAFKLLSAV971DILGEKFGIG981LPILFLRGSN991SQRLADQYRR
1001-10501001HSLFGTGKDQ1011TESWWKAFSR1021QLITEGFLVE1031VSRYNKFMKI1041CALTKKGRNW
1051-11001051LHKANTESQS1061LILQANEELC1071PKKLLLPSSK1081TVSSGTKEHC1091YNQVPVELST
1101-11501101EKKSNLEKLY1111SYKPCDKISS1121GSNISKKSIM1131VQSPEKAYSS1141SQPVISAQEQ
1151-12001151ETQIVLYGKL1161VEARQKHANK1171MDVPPAILAT1181NKILVDMAKM1191RPTTVENVKR
1201-12501201IDGVSEGKAA1211MLAPLLEVIK1221HFCQTNSVQT1231DLFSSTKPQE1241EQKTSLVAKN
1251-13001251KICTLSQSMA1261ITYSLFQEKK1271MPLKSIAESR1281ILPLMTIGMH1291LSQAVKAGCP
1301-13501301LDLERAGLTP1311EVQKIIADVI1321RNPPVNSDMS1331KISLIRMLVP1341ENIDTYLIHM
1351-14001351AIEILKHGPD1361SGLQPSCDVN1371KRRCFPGSEE1381ICSSSKRSKE1391EVGINTETSS
1401-14321401AERKRRLPVW1411FAKGSDTSKK1421LMDKTKRGGL1431FS
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
34 Prediction (Medium) - -
103 Prediction (High) - -
171 Prediction (Medium) - -
197 Prediction (Low) - -
580 Prediction (Medium) - -
617 Prediction (Low) - -
646 Prediction (Low) - -
727 Prediction (Low) - -
791 Prediction (Low) - -
817 Experimental Helicase conserved C-terminal domain 37611173
864 Prediction (Low) - -
908 Prediction (Low) - -
1041 Prediction (High) - -
1070 Prediction (High) - -
1223 Prediction (Low) - -
1253 Prediction (Medium) - -
1299 Experimental Prediction (Medium) Helix-turn-helix domain 37611173
1367 Prediction (Low) - -
1382 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
196 R → C 0.005618 SNP Missense Mutation PAAD
436 Y → C 0.002427 SNP Missense Mutation BLCA
596 S → C 0.002427 SNP Missense Mutation BLCA
946 C → Y 0.001887 SNP Missense Mutation UCEC
1041 C → C 0.001014 SNP Silent BRCA
1264 S → C 0.005435 SNP Missense Mutation ESCA
1374 C → F 0.001887 SNP Missense Mutation UCEC
1429 G → C 0.001764 SNP Missense Mutation LUAD