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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q14254 FLOT2; ESA1; M17S1 Flotillin-2 (Epidermal surface antigen) (ESA) … Homo sapiens (Human) 428 aa

Protein Details: Q14254 (FLOT2)

Protein Information
Accession Q14254
Protein Names Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1)
Gene Symbol FLOT2; ESA1; M17S1
Organism Homo sapiens (Human)
Length 428 aa
Isoforms No isoforms
Related PMIDs 19801377 22496122 24357059 26111759 29575903 29733200 31251020 32944167 33636221 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.512
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
44
LNCaP cells
Specificity: 0.512
44/46 (95.7%)
10
HAP1 cells
Specificity: 0.116
10/10 (100.0%)
10
293T cells
Specificity: 0.116
10/10 (100.0%)
4
Jurkat T cells
Specificity: 0.047
4/25 (16.0%)
4
PC3 cells
Specificity: 0.047
4/4 (100.0%)
4
T cells
Specificity: 0.047
4/4 (100.0%)
4
Cerebral cortex
Specificity: 0.047
4/4 (100.0%)
2
DU145 cells
Specificity: 0.023
2/2 (100.0%)
2
Endothelial cells
Specificity: 0.023
2/2 (100.0%)
1
HeLa cells
Specificity: 0.012
1/1 (100.0%)
1
Liver membrane
Specificity: 0.012
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGNCHTVGPN11EALVVSGGCC21GSDYKQYVFG31GWAWAWWCIS41DTQRISLEIM
51-10051TLQPRCEDVE61TAEGVALTVT71GVAQVKIMTE81KELLAVACEQ91FLGKNVQDIK
101-150101NVVLQTLEGH111LRSILGTLTV121EQIYQDRDQF131AKLVREVAAP141DVGRMGIEIL
151-200151SFTIKDVYDK161VDYLSSLGKT171QTAVVQRDAD181IGVAEAERDA191GIREAECKKE
201-250201MLDVKFMADT211KIADSKRAFE221LQKSAFSEEV231NIKTAEAQLA241YELQGAREQQ
251-300251KIRQEEIEIE261VVQRKKQIAV271EAQEILRTDK281ELIATVRRPA291EAEAHRIQQI
301-350301AEGEKVKQVL311LAQAEAEKIR321KIGEAEAAVI331EAMGKAEAER341MKLKAEAYQK
351-400351YGDAAKMALV361LEALPQIAAK371IAAPLTKVDE381IVVLSGDNSK391VTSEVNRLLA
401-428401ELPASVHALT411GVDLSKIPLI421KKATGVQV
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
4 DBPTM SWISSPALM Prediction (High) - -
19 DBPTM SWISSPALM Prediction (Low) - -
20 DBPTM SWISSPALM - -
38 Prediction (Low) - -
88 Experimental CYSMODDB SWISSPALM DBPTM Prediction (Low) - 29575903
197 Experimental CYSMODDB SWISSPALM DBPTM Prediction (Medium) - 29575903
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
55 R → C 0.003460 SNP Missense Mutation CESC
191 G → C 0.001887 SNP Missense Mutation UCEC
247 R → C 0.002288 SNP Missense Mutation STAD
287 R → C 0.002288 SNP Missense Mutation STAD