Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q14254 | FLOT2 | Flotillin-2 (Epidermal surface antigen) (ESA) … | Homo sapiens (Human) | 428 aa |
Protein Details: Q14254 (FLOT2)
Protein Information
| Accession | Q14254 |
|---|---|
| Protein Names | Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1) |
| Gene Symbol | FLOT2 |
| Organism | Homo sapiens (Human) |
| Length | 428 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 22496122 24357059 26111759 29575903 29733200 31251020 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGNCHTVGPN11EALVVSGGCC21GSDYKQYVFG31GWAWAWWCIS41DTQRISLEIM
51-10051TLQPRCEDVE61TAEGVALTVT71GVAQVKIMTE81KELLAVACEQ91FLGKNVQDIK
101-150101NVVLQTLEGH111LRSILGTLTV121EQIYQDRDQF131AKLVREVAAP141DVGRMGIEIL
151-200151SFTIKDVYDK161VDYLSSLGKT171QTAVVQRDAD181IGVAEAERDA191GIREAECKKE
201-250201MLDVKFMADT211KIADSKRAFE221LQKSAFSEEV231NIKTAEAQLA241YELQGAREQQ
251-300251KIRQEEIEIE261VVQRKKQIAV271EAQEILRTDK281ELIATVRRPA291EAEAHRIQQI
301-350301AEGEKVKQVL311LAQAEAEKIR321KIGEAEAAVI331EAMGKAEAER341MKLKAEAYQK
351-400351YGDAAKMALV361LEALPQIAAK371IAAPLTKVDE381IVVLSGDNSK391VTSEVNRLLA
401-428401ELPASVHALT411GVDLSKIPLI421KKATGVQV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 4 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.03
|
| 19 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.75
|
| 20 | DBPTM SWISSPALM | - | - |
Jurkat T
(32651440)
|
Deep-Palm: 0.69
|
| 38 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.09
|
|
| 56 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
Deep-Palm: 0.96
|
|
| 88 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
GPS-Palm: 0.72
Deep-Palm: 0.97
|
| 197 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
GPS-Palm: 0.79
Deep-Palm: 0.90
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.192
5
Jurkat T cell
Specificity: 0.161
5/5 (100.0%)
4
LNCaP
Specificity: 0.129
4/4 (100.0%)
4
Primary T cell
Specificity: 0.129
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.129
4/4 (100.0%)
2
HAP1 cell
Specificity: 0.065
2/2 (100.0%)
2
HeLa cell
Specificity: 0.065
2/2 (100.0%)
2
293T cell
Specificity: 0.065
2/2 (100.0%)
1
EC cell
Specificity: 0.032
1/1 (100.0%)
1
heart
Specificity: 0.032
1/1 (100.0%)
1
HUVECs
Specificity: 0.032
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.129
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.032
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 55 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 191 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 247 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 287 | R → C | 0.002288 | SNP | Missense Mutation | STAD |