Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q14289 PTK2B Protein-tyrosine kinase 2-beta (EC 2.7.10.2) … Homo sapiens (Human) 1009 aa

Protein Details: Q14289 (PTK2B)

Protein Information
AccessionQ14289
Protein NamesProtein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Gene SymbolPTK2B
OrganismHomo sapiens (Human)
Length1009 aa
IsoformsNo isoforms
Related PMIDs 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MSGVSEPLSR11VKLGTLRRPE21GPAEPMVVVP31VDVEKEDVRI41LKVCFYSNSF
51-10051NPGKNFKLVK61CTVQTEIREI71ITSILLSGRI81GPNIRLAECY91GLRLKHMKSD
101-150101EIHWLHPQMT111VGEVQDKYEC121LHVEAEWRYD131LQIRYLPEDF141MESLKEDRTT
151-200151LLYFYQQLRN161DYMQRYASKV171SEGMALQLGC181LELRRFFKDM191PHNALDKKSN
201-250201FELLEKEVGL211DLFFPKQMQE221NLKPKQFRKM231IQQTFQQYAS241LREEECVMKF
251-300251FNTLAGFANI261DQETYRCELI271QGWNITVDLV281IGPKGIRQLT291SQDAKPTCLA
301-350301EFKQIRSIRC311LPLEEGQAVL321QLGIEGAPQA331LSIKTSSLAE341AENMADLIDG
351-400351YCRLQGEHQG361SLIIHPRKDG371EKRNSLPQIP381MLNLEARRSH391LSESCSIESD
401-450401IYAEIPDETL411RRPGGPQYGI421AREDVVLNRI431LGEGFFGEVY441EGVYTNHKGE
451-500451KINVAVKTCK461KDCTLDNKEK471FMSEAVIMKN481LDHPHIVKLI491GIIEEEPTWI
501-550501IMELYPYGEL511GHYLERNKNS521LKVLTLVLYS531LQICKAMAYL541ESINCVHRDI
551-600551AVRNILVASP561ECVKLGDFGL571SRYIEDEDYY581KASVTRLPIK591WMSPESINFR
601-650601RFTTASDVWM611FAVCMWEILS621FGKQPFFWLE631NKDVIGVLEK641GDRLPKPDLC
651-700651PPVLYTLMTR661CWDYDPSDRP671RFTELVCSLS681DVYQMEKDIA691MEQERNARYR
701-750701TPKILEPTAF711QEPPPKPSRP721KYRPPPQTNL731LAPKLQFQVP741EGLCASSPTL
751-800751TSPMEYPSPV761NSLHTPPLHR771HNVFKRHSMR781EEDFIQPSSR791EEAQQLWEAE
801-850801KVKMRQILDK811QQKQMVEDYQ821WLRQEEKSLD831PMVYMNDKSP841LTPEKEVGYL
851-900851EFTGPPQKPP861RLGAQSIQPT871ANLDRTDDLV881YLNVMELVRA891VLELKNELCQ
901-950901LPPEGYVVVV911KNVGLTLRKL921IGSVDDLLPS931LPSSSRTEIE941GTQKLLNKDL
951-1000951AELINKMRLA961QQNAVTSLSE971ECKRQMLTAS981HTLAVDAKNL991LDAVDQAKVL
1001-10091001ANLAHPPAE
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
44 Focal adhesion kinase, N-terminal - -
GPS-Palm: 0.93
Deep-Palm: 0.88
61 - - -
GPS-Palm: 0.87
Deep-Palm: 0.79
89 - - -
GPS-Palm: 0.94
Deep-Palm: 0.91
120 - - -
Deep-Palm: 0.19
180 - - -
GPS-Palm: 0.95
Deep-Palm: 0.94
246 - - -
Deep-Palm: 0.16
267 - - -
Deep-Palm: 0.38
298 - - -
GPS-Palm: 0.91
Deep-Palm: 0.93
310 - - -
GPS-Palm: 0.70
Deep-Palm: 0.96
352 - - -
Deep-Palm: 0.73
395 - - -
Deep-Palm: 0.73
459 - - -
GPS-Palm: 0.82
Deep-Palm: 0.20
463 SWISSPALM DBPTM CYSMODDB Protein tyrosine and serine/threonine kinase - -
GPS-Palm: 0.87
Deep-Palm: 0.67
534 - - -
GPS-Palm: 0.75
Deep-Palm: 0.27
545 - - -
GPS-Palm: 0.86
Deep-Palm: 0.45
562 - -
cerebral cortex (36430497)
GPS-Palm: 0.86
Deep-Palm: 0.92
614 - - -
Deep-Palm: 0.03
650 - - -
Deep-Palm: 0.29
661 - - -
Deep-Palm: 0.13
677 - - -
GPS-Palm: 0.69
Deep-Palm: 0.28
744 - - -
Deep-Palm: 0.92
899 - - -
Deep-Palm: 0.98
972 - - -
GPS-Palm: 0.67
Deep-Palm: 0.89
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 1.000
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
89 C → C 0.003460 SNP Silent CESC
134 R → C 0.002288 SNP Missense Mutation STAD
134 R → C 0.002141 SNP Missense Mutation SKCM
162 Y → C 0.001887 SNP Missense Mutation UCEC
165 R → C 0.002288 SNP Missense Mutation STAD
165 R → C 0.001887 SNP Missense Mutation UCEC
440 Y → C 0.002747 SNP Missense Mutation LIHC
442 G → C 0.002294 SNP Missense Mutation OV
507 Y → C 0.001969 SNP Missense Mutation HNSC
534 C → Y 0.001887 SNP Missense Mutation UCEC
586 R → C 0.002506 SNP Missense Mutation COAD
586 R → C 0.002141 SNP Missense Mutation SKCM
664 Y → C 0.002288 SNP Missense Mutation STAD
664 Y → C 0.002506 SNP Missense Mutation COAD
671 R → C 0.002288 SNP Missense Mutation STAD
699 Y → C 0.001887 SNP Missense Mutation UCEC