Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q14432 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC … Homo sapiens (Human) 1141 aa

Protein Details: Q14432 (PDE3A)

Protein Information
AccessionQ14432
Protein NamescGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)
Gene SymbolPDE3A
OrganismHomo sapiens (Human)
Length1141 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAVPGDAARV11RDKPVHSGVS21QAPTAGRDCH31HRADPASPRD41SGCRGCWGDL
51-10051VLQPLRSSRK61LSSALCAGSL71SFLLALLVRL81VRGEVGCDLE91QCKEAAAAEE
101-150101EEAAPGAEGG111VFPGPRGGAP121GGGARLSPWL131QPSALLFSLL141CAFFWMGLYL
151-200151LRAGVRLPLA161VALLAACCGG171EALVQIGLGV181GEDHLLSLPA191AGVVLSCLAA
201-250201ATWLVLRLRL211GVLMIALTSA221VRTVSLISLE231RFKVAWRPYL241AYLAGVLGIL
251-300251LARYVEQILP261QSAEAAPREH271LGSQLIAGTK281EDIPVFKRRR291RSSSVVSAEM
301-350301SGCSSKSHRR311TSLPCIPREQ321LMGHSEWDHK331RGPRGSQSSG341TSITVDIAVM
351-400351GEAHGLITDL361LADPSLPPNV371CTSLRAVSNL381LSTQLTFQAI391HKPRVNPVTS
401-450401LSENYTCSDS411EESSEKDKLA421IPKRLRRSLP431PGLLRRVSST441WTTTTSATGL
451-500451PTLEPAPVRR461DRSTSIKLQE471APSSSPDSWN481NPVMMTLTKS491RSFTSSYAIS
501-550501AANHVKAKKQ511SRPGALAKIS521PLSSPCSSPL531QGTPASSLVS541KISAVQFPES
551-600551ADTTAKQSLG561SHRALTYTQS571APDLSPQILT581PPVICSSCGR591PYSQGNPADE
601-650601PLERSGVATR611TPSRTDDTAQ621VTSDYETNNN631SDSSDIVQNE641DETECLREPL
651-700651RKASACSTYA661PETMMFLDKP671ILAPEPLVMD681NLDSIMEQLN691TWNFPIFDLV
701-750701ENIGRKCGRI711LSQVSYRLFE721DMGLFEAFKI731PIREFMNYFH741ALEIGYRDIP
751-800751YHNRIHATDV761LHAVWYLTTQ771PIPGLSTVIN781DHGSTSDSDS791DSGFTHGHMG
801-850801YVFSKTYNVT811DDKYGCLSGN821IPALELMALY831VAAAMHDYDH841PGRTNAFLVA
851-900851TSAPQAVLYN861DRSVLENHHA871AAAWNLFMSR881PEYNFLINLD891HVEFKHFRFL
901-950901VIEAILATDL911KKHFDFVAKF921NGKVNDDVGI931DWTNENDRLL941VCQMCIKLAD
951-1000951INGPAKCKEL961HLQWTDGIVN971EFYEQGDEEA981SLGLPISPFM991DRSAPQLANL
1001-10501001QESFISHIVG1011PLCNSYDSAG1021LMPGKWVEDS1031DESGDTDDPE1041EEEEEAPAPN
1051-11001051EEETCENNES1061PKKKTFKRRK1071IYCQITQHLL1081QNHKMWKKVI1091EEEQRLAGIE
1101-11411101NQSLDQTPQS1111HSSEQIQAIK1121EEEEEKGKPR1131GEEIPTQKPD1141Q
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
29 - - -
Deep-Palm: 0.31
43 - - -
Deep-Palm: 0.67
46 - - -
GPS-Palm: 0.72
Deep-Palm: 0.92
66 - - -
GPS-Palm: 0.79
Deep-Palm: 0.98
87 - - -
GPS-Palm: 0.78
Deep-Palm: 0.98
92 - - -
Deep-Palm: 0.98
141 -
HeLa (37611173)
-
Deep-Palm: 0.90
167 - - -
GPS-Palm: 0.91
Deep-Palm: 0.98
168 - - -
GPS-Palm: 0.89
Deep-Palm: 0.98
197 - - -
GPS-Palm: 0.74
Deep-Palm: 0.98
303 - - -
GPS-Palm: 0.68
Deep-Palm: 0.93
315 - - -
GPS-Palm: 0.77
Deep-Palm: 0.52
371 - - -
GPS-Palm: 0.67
Deep-Palm: 0.96
407 - - -
Deep-Palm: 0.77
526 - - -
GPS-Palm: 0.69
Deep-Palm: 0.97
585 - - -
GPS-Palm: 0.72
Deep-Palm: 0.78
588 - - -
GPS-Palm: 0.66
Deep-Palm: 0.80
645 - - -
GPS-Palm: 0.66
Deep-Palm: 0.84
656 - - -
GPS-Palm: 0.77
Deep-Palm: 0.94
707 - - -
GPS-Palm: 0.77
Deep-Palm: 0.72
816 - - -
Deep-Palm: 0.75
942 - - -
GPS-Palm: 0.72
Deep-Palm: 0.27
945 - - -
GPS-Palm: 0.71
Deep-Palm: 0.39
957 - - -
Deep-Palm: 0.12
1013 - - -
Deep-Palm: 0.37
1055 - - -
Deep-Palm: 0.72
1073 - - -
GPS-Palm: 0.82
Deep-Palm: 0.36
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
66 C → C 0.002506 SNP Silent COAD
156 R → C 0.005618 SNP Missense Mutation PAAD
302 G → C 0.001764 SNP Missense Mutation LUAD
327 W → C 0.003460 SNP Missense Mutation CESC
365 S → C 0.002427 SNP Missense Mutation BLCA
407 C → Ffs*19 0.002288 DEL Frame Shift Del STAD
424 R → C 0.002288 SNP Missense Mutation STAD
424 R → C 0.002545 SNP Missense Mutation GBM
441 W → C 0.002033 SNP Missense Mutation LUSC
449 G → C 0.001969 SNP Missense Mutation HNSC
526 C → C 0.001887 SNP Silent UCEC
585 C → F 0.002294 SNP Missense Mutation OV
625 Y → C 0.002545 SNP Missense Mutation GBM
692 W → C 0.002288 SNP Missense Mutation STAD
707 C → G 0.001887 SNP Missense Mutation UCEC
709 R → C 0.003774 SNP Missense Mutation UCEC
716 Y → C 0.002288 SNP Missense Mutation STAD
723 G → C 0.002033 SNP Missense Mutation LUSC
728 F → C 0.001887 SNP Missense Mutation UCEC
739 F → C 0.001887 SNP Missense Mutation UCEC
932 W → C 0.002294 SNP Missense Mutation OV
938 R → C 0.002141 SNP Missense Mutation SKCM
938 R → C 0.001887 SNP Missense Mutation UCEC
992 R → C 0.007299 SNP Missense Mutation READ
992 R → C 0.002141 SNP Missense Mutation SKCM
992 R → C 0.003460 SNP Missense Mutation CESC
1013 C → Sfs*9 0.002033 DEL Frame Shift Del LUSC
1055 C → C 0.002288 SNP Silent STAD
1112 S → C 0.001969 SNP Missense Mutation HNSC