Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
Q14566 MCM6 DNA replication licensing factor MCM6 … Homo sapiens (Human) 821 aa

Protein Details: Q14566 (MCM6)

Protein Information
AccessionQ14566
Protein NamesDNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)
Gene SymbolMCM6
OrganismHomo sapiens (Human)
Length821 aa
IsoformsNo isoforms
Related PMIDs 24357059 29733200 31251020 31382980 32944167
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MDLAAAAEPG11AGSQHLEVRD21EVAEKCQKLF31LDFLEEFQSS41DGEIKYLQLA
51-10051EELIRPERNT61LVVSFVDLEQ71FNQQLSTTIQ81EEFYRVYPYL91CRALKTFVKD
101-150101RKEIPLAKDF111YVAFQDLPTR121HKIRELTSSR131IGLLTRISGQ141VVRTHPVHPE
151-200151LVSGTFLCLD161CQTVIRDVEQ171QFKYTQPNIC181RNPVCANRRR191FLLDTNKSRF
201-250201VDFQKVRIQE211TQAELPRGSI221PRSLEVILRA231EAVESAQAGD241KCDFTGTLIV
251-300251VPDVSKLSTP261GARAETNSRV271SGVDGYETEG281IRGLRALGVR291DLSYRLVFLA
301-350301CCVAPTNPRF311GGKELRDEEQ321TAESIKNQMT331VKEWEKVFEM341SQDKNLYHNL
351-400351CTSLFPTIHG361NDEVKRGVLL371MLFGGVPKTT381GEGTSLRGDI391NVCIVGDPST
401-450401AKSQFLKHVE411EFSPRAVYTS421GKASSAAGLT431AAVVRDEESH441EFVIEAGALM
451-500451LADNGVCCID461EFDKMDVRDQ471VAIHEAMEQQ481TISITKAGVK491ATLNARTSIL
501-550501AAANPISGHY511DRSKSLKQNI521NLSAPIMSRF531DLFFILVDEC541NEVTDYAIAR
551-600551RIVDLHSRIE561ESIDRVYSLD571DIRRYLLFAR581QFKPKISKES591EDFIVEQYKH
601-650601LRQRDGSGVT611KSSWRITVRQ621LESMIRLSEA631MARMHCCDEV641QPKHVKEAFR
651-700651LLNKSIIRVE661TPDVNLDQEE671EIQMEVDEGA681GGINGHADSP691APVNGINGYN
701-750701EDINQESAPK711ASLRLGFSEY721CRISNLIVLH731LRKVEEEEDE741SALKRSELVN
751-800751WYLKEIESEI761DSEEELINKK771RIIEKVIHRL781THYDHVLIEL791TQAGLKGSTE
801-821801GSESYEEDPY811LVVNPNYLLE821D
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
26 - - -
Deep-Palm: 0.91
91 - - -
GPS-Palm: 0.91
Deep-Palm: 0.92
158 -
HeLa (37611173)
-
Deep-Palm: 0.47
161 -
HeLa (37611173)
-
GPS-Palm: 0.85
Deep-Palm: 0.45
180 - - -
GPS-Palm: 0.90
Deep-Palm: 0.25
185 - - -
GPS-Palm: 0.89
Deep-Palm: 0.17
242 - - -
Deep-Palm: 0.97
301 - - -
GPS-Palm: 0.95
Deep-Palm: 0.97
302 - - -
GPS-Palm: 0.94
Deep-Palm: 0.96
351 - - -
Deep-Palm: 0.37
393 - - -
GPS-Palm: 0.77
Deep-Palm: 0.94
457 - - -
GPS-Palm: 0.74
Deep-Palm: 0.88
458 - - -
GPS-Palm: 0.71
Deep-Palm: 0.93
540 - - -
Deep-Palm: 0.59
636 - - -
GPS-Palm: 0.69
Deep-Palm: 0.79
637 - - -
GPS-Palm: 0.67
Deep-Palm: 0.75
721 - - -
GPS-Palm: 0.86
Deep-Palm: 0.95
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.375
3
PC3
Specificity: 0.375
3/3 (100.0%)
1
LNCaP
Specificity: 0.125
1/1 (100.0%)
1
HAP1 cell
Specificity: 0.125
1/1 (100.0%)
1
U937 cell
Specificity: 0.125
1/1 (100.0%)
1
293T cell
Specificity: 0.125
1/1 (100.0%)
1
HUVECs
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
101 R → C 0.002506 SNP Missense Mutation COAD
207 R → C 0.002141 SNP Missense Mutation SKCM
551 R → C 0.005618 SNP Missense Mutation PAAD
565 R → C 0.002141 SNP Missense Mutation SKCM
626 R → C 0.002141 SNP Missense Mutation SKCM
658 R → C 0.005618 SNP Missense Mutation PAAD
679 G → C 0.001764 SNP Missense Mutation LUAD
707 S → C 0.002033 SNP Missense Mutation LUSC
724 S → C 0.002427 SNP Missense Mutation BLCA
301* C → ? 0.002288 SNP Nonsense Mutation STAD