Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q14566 | MCM6 | DNA replication licensing factor MCM6 … | Homo sapiens (Human) | 821 aa |
Protein Details: Q14566 (MCM6)
Protein Information
| Accession | Q14566 |
|---|---|
| Protein Names | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) |
| Gene Symbol | MCM6 |
| Organism | Homo sapiens (Human) |
| Length | 821 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 21076176 24357059 29733200 31251020 31382980 32944167 37611173 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.294
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
10
HAP1 cells
Specificity: 0.294
10/10 (100.0%)
9
LNCaP cells
Specificity: 0.265
9/46 (19.6%)
6
Jurkat T cells
Specificity: 0.176
6/25 (24.0%)
4
293T cells
Specificity: 0.118
4/10 (40.0%)
3
PC3 cells
Specificity: 0.088
3/4 (75.0%)
1
U937 cells
Specificity: 0.029
1/1 (100.0%)
1
Endothelial cells
Specificity: 0.029
1/2 (50.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MDLAAAAEPG11AGSQHLEVRD21EVAEKCQKLF31LDFLEEFQSS41DGEIKYLQLA
51-10051EELIRPERNT61LVVSFVDLEQ71FNQQLSTTIQ81EEFYRVYPYL91CRALKTFVKD
101-150101RKEIPLAKDF111YVAFQDLPTR121HKIRELTSSR131IGLLTRISGQ141VVRTHPVHPE
151-200151LVSGTFLCLD161CQTVIRDVEQ171QFKYTQPNIC181RNPVCANRRR191FLLDTNKSRF
201-250201VDFQKVRIQE211TQAELPRGSI221PRSLEVILRA231EAVESAQAGD241KCDFTGTLIV
251-300251VPDVSKLSTP261GARAETNSRV271SGVDGYETEG281IRGLRALGVR291DLSYRLVFLA
301-350301CCVAPTNPRF311GGKELRDEEQ321TAESIKNQMT331VKEWEKVFEM341SQDKNLYHNL
351-400351CTSLFPTIHG361NDEVKRGVLL371MLFGGVPKTT381GEGTSLRGDI391NVCIVGDPST
401-450401AKSQFLKHVE411EFSPRAVYTS421GKASSAAGLT431AAVVRDEESH441EFVIEAGALM
451-500451LADNGVCCID461EFDKMDVRDQ471VAIHEAMEQQ481TISITKAGVK491ATLNARTSIL
501-550501AAANPISGHY511DRSKSLKQNI521NLSAPIMSRF531DLFFILVDEC541NEVTDYAIAR
551-600551RIVDLHSRIE561ESIDRVYSLD571DIRRYLLFAR581QFKPKISKES591EDFIVEQYKH
601-650601LRQRDGSGVT611KSSWRITVRQ621LESMIRLSEA631MARMHCCDEV641QPKHVKEAFR
651-700651LLNKSIIRVE661TPDVNLDQEE671EIQMEVDEGA681GGINGHADSP691APVNGINGYN
701-750701EDINQESAPK711ASLRLGFSEY721CRISNLIVLH731LRKVEEEEDE741SALKRSELVN
751-800751WYLKEIESEI761DSEEELINKK771RIIEKVIHRL781THYDHVLIEL791TQAGLKGSTE
801-821801GSESYEEDPY811LVVNPNYLLE821D
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 91 | Prediction (High) | - | - |
| 158 | Experimental | MCM OB domain | 37611173 |
| 161 | Experimental Prediction (Medium) | MCM OB domain | 37611173 |
| 180 | Prediction (High) | - | - |
| 185 | Prediction (High) | - | - |
| 301 | Prediction (High) | - | - |
| 302 | Prediction (High) | - | - |
| 393 | Prediction (Low) | - | - |
| 457 | Prediction (Low) | - | - |
| 458 | Prediction (Low) | - | - |
| 636 | Prediction (Low) | - | - |
| 637 | Prediction (Low) | - | - |
| 721 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 101 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 207 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 551 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 565 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 626 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 658 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 679 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 707 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 724 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 301* | C → ? | 0.002288 | SNP | Nonsense Mutation | STAD |