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UniProt ID Gene Symbol Protein Name Organism Length Action
Q14654 KCNJ11 ATP-sensitive inward rectifier potassium channel … Homo sapiens (Human) 390 aa

Protein Details: Q14654 (KCNJ11)

Protein Information
AccessionQ14654
Protein NamesATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)
Gene SymbolKCNJ11
OrganismHomo sapiens (Human)
Length390 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MLSRKGIIPE11EYVLTRLAED21PAKPRYRARQ31RRARFVSKKG41NCNVAHKNIR
51-10051EQGRFLQDVF61TTLVDLKWPH71TLLIFTMSFL81CSWLLFAMAW91WLIAFAHGDL
101-150101APSEGTAEPC111VTSIHSFSSA121FLFSIEVQVT131IGFGGRMVTE141ECPLAILILI
151-200151VQNIVGLMIN161AIMLGCIFMK171TAQAHRRAET181LIFSKHAVIA191LRHGRLCFML
201-250201RVGDLRKSMI211ISATIHMQVV221RKTTSPEGEV231VPLHQVDIPM241ENGVGGNSIF
251-300251LVAPLIIYHV261IDANSPLYDL271APSDLHHHQD281LEIIVILEGV291VETTGITTQA
301-350301RTSYLADEIL311WGQRFVPIVA321EEDGRYSVDY331SKFGNTVKVP341TPLCTARQLD
351-390351EDHSLLEALT361LASARGPLRK371RSVPMAKAKP381KFSISPDSLS
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
42 Potassium channel, inwardly rectifying, transmembrane domain - -
GPS-Palm: 0.79
Deep-Palm: 0.81
81 - - -
Deep-Palm: 0.05
110 - - -
Deep-Palm: 0.86
142 - - -
GPS-Palm: 0.73
Deep-Palm: 0.88
166 SWISSPALM Inward rectifier potassium channel transmembrane domain - -
GPS-Palm: 0.87
Deep-Palm: 0.70
197 - - -
GPS-Palm: 0.91
Deep-Palm: 0.76
344 - - -
GPS-Palm: 0.82
Deep-Palm: 0.94
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
16 R → C 0.001764 SNP Missense Mutation LUAD
29 R → C 0.001969 SNP Missense Mutation HNSC
81 C → C 0.001887 SNP Silent UCEC
110 C → F 0.002033 SNP Missense Mutation LUSC
176 R → C 0.002506 SNP Missense Mutation COAD
206 R → C 0.001887 SNP Missense Mutation UCEC
369 R → C 0.001887 SNP Missense Mutation UCEC
371 R → C 0.001887 SNP Missense Mutation UCEC
? ? → ? 0.002288 SNP Missense Mutation STAD