Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| Q14699 | RFTN1 | Raftlin (Cell migration-inducing gene 2 … | Homo sapiens (Human) | 578 aa |
Protein Details: Q14699 (RFTN1)
Protein Information
| Accession | Q14699 |
|---|---|
| Protein Names | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) |
| Gene Symbol | RFTN1 |
| Organism | Homo sapiens (Human) |
| Length | 578 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 33636221 |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGCGLNKLEK11RDEKRPGNIY21STLKRPQVET31KIDVSYEYRF41LEFTTLSAAE
51-10051LPGSSAVRLA61SLRDLPAQLL71ELYQQGFSLA81ALHPFVQPTH91EREKTPLEHI
101-150101FRAILIKKTD111RSQKTDLHNE121GYILELDCCS131SLDHPTDQKL141IPEFIKKIQE
151-200151AASQGLKFVG161VIPQYHSSVN171SAGSSAPVST181ANSTEDARDA191KNARGDHASL
201-250201ENEKPGTGDV211CSAPAGRNQS221PEPSSGPRGE231VPLAKQPSSP241SGEGDGGELS
251-300251PQGVSKTLDG261PESNPLEVHE271EPLSGKMEIF281TLFNKPKSHQ291KCRQYYPVTI
301-350301PLHVSKNGQT311VSGLDANWLE321HMSDHFRKGG331MLVNAVFYLG341IVNDSLHGLT
351-400351DGVFIFEAVS361TEDSKTIQGY371DAIVVEQWTV381LEGVEVQTDY391VPLLNSLAAY
401-450401GWQLTCVLPT411PVVKTTSEGS421VSTKQIVFLQ431RPCLPQKIKK441KESKFQWRFS
451-500451REEMHNRQMR461KSKGKLSARD471KQQAEENEKN481LEDQSSKAGD491MGNCVSGQQQ
501-550501EGGVSEEMKG511PVQEDKGEQL521SPGGLLCGVG531VEGEAVQNGP541ASHSRALVGI
551-578551CTGHSNPGED561ARDGDAEEVR571ELGTVEEN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 3 | DBPTM | Raftlin family Raftlin | - | - |
GPS-Palm: 0.98
Deep-Palm: 0.03
|
| 128 | - | - | - |
Deep-Palm: 0.49
|
|
| 129 | - | - | - |
Deep-Palm: 0.69
|
|
| 211 | - | - | - |
Deep-Palm: 0.75
|
|
| 292 | - | - | - |
Deep-Palm: 0.12
|
|
| 406 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.96
|
|
| 433 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.90
|
|
| 494 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.86
|
|
| 527 | - | - | - |
Deep-Palm: 0.96
|
|
| 551 | - | - | - |
Deep-Palm: 0.85
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.429
3
Primary T cell
Specificity: 0.429
3/3 (100.0%)
3
Jurkat T cell
Specificity: 0.429
3/3 (100.0%)
1
heart
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 128 | C → C | 0.005618 | SNP | Silent | PAAD |
| 194 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 296 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |